構造生物学研究の新展開　　２．基礎研究から応用展開に向けて（ｃ）応用志向型研究　　高機能化ホタル・ルシフェラーゼ創製に向けて

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タイトル別名
  • Creation of High Efficient Firefly Luciferase
  • 高機能化ホタル・ルシフェラーゼ創製に向けて
  • コウキノウカ ホタル ルシフェラーゼ ソウセイ ニ ムケテ

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抄録

Firefly emits visible yellow-green light. The bioluminescence reaction is carried out by the enzyme luciferase. The bioluminescence of luciferase is widely used as an excellent tool for monitoring gene expression, the measurement of the amount of ATP and in vivo imaging. Recently a study of the cancer metastasis is carried out by in vivo luminescence imaging system, because luminescence imaging is less toxic and more useful for long-term assay than fluorescence imaging by GFP. However the luminescence is much dimmer than fluorescence. Then bioluminescence imaging in living organisms demands the high efficient luciferase which emits near infrared lights or enhances the emission intensity. Here I introduce an idea for creating the high efficient luciferase based on the crystal structure.

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