Effects of Different Statin Treatments on Small Dense Low-Density Lipoprotein in Patients with Metabolic Syndrome
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- Bahadir Muzeyyen Aslan
- Internist, Goztepe Training and Research Hospital, Department of Internal Medicine.
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- Oguz Aytekin
- Professor of Medicine, Goztepe Training and Research Hospital, Department of Internal Medicine.
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- Uzunlulu Mehmet
- Associate Professor, Goztepe Training and Research Hospital, Department of Internal Medicine.
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- Bahadir Ozgur
- Internist, Goztepe Training and Research Hospital, Department of Internal Medicine.
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Aim: To compare the effects of different low-density lipoprotein (LDL) cholesterol-lowering statin treatments on small dense LDL (sd-LDL) in hypercholesterolemic patients with metabolic syndrome (MetS).<BR>Methods: Forty hypercholesterolemic MetS patients ?30 years of age were randomized to rosuvas-tatin (n=17) or other statins (n=23) groups. In the other statins group, those taking atorvastatin (n=12) were also evaluated separately. Statin doses were 10 mg/day rosuvastatin, 20 mg/day atorvas-tatin, 40 mg/day simvastatin, and 40 mg/day pravastatin. Treatment duration was planned to be 8 weeks. Sd-LDL levels were assessed at baseline and at the completion of treatment.<BR>Results: After treatment, sd-LDL levels were significantly reduced in all 3 groups (from 29.6±24.8 mg/dL to 8.9±8.5 mg/dL in the rosuvastatin group, p=0.001; from 26.2±15 mg/dL to 14.8±9.6 mg/dL in the atorvastatin group, p=0.02; and from 29.1±16.5 mg/dL to 14.7±11.2 mg/dL in the other statins group, p=0.0001). There was no significant difference in the mean percent changes among groups.<BR>Conclusion: Significant reduction in sd-LDL levels was observed after 8 weeks of statin treatment in hypercholesterolemic patients with MetS. This effect was similar for all statins and can be considered a class effect.
収録刊行物
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- Journal of Atherosclerosis and Thrombosis
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Journal of Atherosclerosis and Thrombosis 16 (5), 684-690, 2009
一般社団法人 日本動脈硬化学会
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詳細情報 詳細情報について
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- CRID
- 1390001204433576064
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- NII論文ID
- 130004444333
- 10026143857
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- NII書誌ID
- AA11018976
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- DOI
- 10.5551/jat.1123
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- ISSN
- 18803873
- 13403478
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可