Possible Association of Atrophic Gastritis and Arterial Stiffness in Healthy Middle-Aged Japanese

• Torisu Takehiro

  Division of General Internal Medicine, Kyushu Dental College Departments of Medicine and Clinical Science, Graduate School of Medicine Science, Kyushu University

• Takata Yutaka

  Division of General Internal Medicine, Kyushu Dental College

• Ansai Toshihiro

  Community Oral Health Science, Department of Health Promotion, Kyushu Dental College

• Matsumoto Takayuki

  Departments of Medicine and Clinical Science, Graduate School of Medicine Science, Kyushu University

• Sonoki Kazuo

  Division of General Internal Medicine, Kyushu Dental College

• Soh Inho

• Awano Shuji

  Community Oral Health Science, Department of Health Promotion, Kyushu Dental College

• Yoshida Akihiro

  Community Oral Health Science, Department of Health Promotion, Kyushu Dental College

• Hamasaki Tomoko

  Community Oral Health Science, Department of Health Promotion, Kyushu Dental College

• Kagiyama Shuntaro

  Division of General Internal Medicine, Kyushu Dental College

• Nakamichi Ikuo

  Division of General Internal Medicine, Kyushu Dental College

• Ohsumi Tomoko

  Applied Pharmacology, Kyushu Dental College

• Toyoshima Kuniaki

  Oral Anatomy and Neurobiology, Kyushu Dental College

• Nishihara Tatsuji

  Infection and Molecular Biology, Kyushu Dental College

• Iida Mitsuo

  Departments of Medicine and Clinical Science, Graduate School of Medicine Science, Kyushu University

• Takehara Tadamichi

  Community Oral Health Science, Department of Health Promotion, Kyushu Dental College

抄録

Aim: Helicobacter pylori (HP) has been implicated as a risk factor for cardiovascular and atherosclerotic diseases. Arterial stiffness determined by pulse wave velocity (PWV) or the cardio-ankle vascular index (CAVI) has been shown to be higher in HP-positive subjects than in HP-negative subjects; however, this result has been observed only in young subjects. The aim of the study was to investigate the possible correlation between HP infection and PWV or CAVI in middle-aged subjects.<BR>Methods: We measured brachial-ankle PWV (baPWV), CAVI, metabolism markers, pepsinogens (PGs) and IgG antibody to HP in 343 individuals aged either 60 or 65 year old. Atrophic gastritis (AG) was diagnosed based on the values of PGs.<BR>Results: baPWV and CAVI were significantly higher in the AG-positive group than in the AG-negative group even after adjusting for possible confounding factors (baPWVc; 16.63±3.50 vs. 15.59±3.47 p=0.010, CAVIc; 8.59±1.20 vs. 8.27±1.19 p=0.022). baPWV and CAVI values tended to be higher in the HP-positive group than in the HP-negative group. High-density lipoprotein (HDL) cholesterol level and the adiponectin level were lower in the AG-positive group than in the AG-negative group.<BR>Conclusion: There may be an association between atrophic gastritis and atherosclerosis in middle-aged subjects.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ

  Ｊｏｕｒｎａｌ　ｏｆ　Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ　ａｎｄ　Ｔｈｒｏｍｂｏｓｉｓ 16 (5), 691-697, 2009

  一般社団法人 日本動脈硬化学会

キーワード

• Pulse wave velocity
• Cardio ankle vascular index
• Helicobacter pylori

詳細情報

• CRID: 1390282679410286592
• NII論文ID: 130004444334
• NII論文ID: 10026143884
• NII書誌ID: AA11018976
• DOI: 10.5551/jat.943
• ISSN: 18803873
• ISSN: 13403478
• Web Site: https://search.jamas.or.jp/link/ui/2010127629
• 本文言語コード: en
• データソース種別:
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