Associations between Blood Lipid Profiles and Risk of Myocardial Infarction Among Japanese Male Workers: 3M Study

• Maruyama Koutatsu

  Public Health, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University.

• Hirobe Kazuhiko

  Osaka Health Promotion and Medical Center, Mizuho Financial Group. 3M-Study Project Committee of the Japan Association of Occupational Physicians “San-yu-kai”.

• Noda Hiroyuki

  Public Health, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University. Harvard Center for Population and Development Studies, Harvard School of Public Health.

• Iso Hiroyasu

  Public Health, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University.

• Dohi Seitaro

  3M-Study Project Committee of the Japan Association of Occupational Physicians “San-yu-kai”.

• Terai Tomohiro

  3M-Study Project Committee of the Japan Association of Occupational Physicians “San-yu-kai”.

• Fujioka Shigenori

  3M-Study Project Committee of the Japan Association of Occupational Physicians “San-yu-kai”.

• Goto Koichi

  3M-Study Project Committee of the Japan Association of Occupational Physicians “San-yu-kai”.

• Horie Seichi

  3M-Study Project Committee of the Japan Association of Occupational Physicians “San-yu-kai”.

• Nakano Shuji

  3M-Study Project Committee of the Japan Association of Occupational Physicians “San-yu-kai”.

Abstract

Aim: To examine whether fasting blood lipid profiles are associated with the risk of myocardial infarc-tion among Japanese men.<BR>Methods: We conducted a nested case-control study in the Morbidity of Myocardial Infarction Mul-ticenter Study in Japan (3M Study). For each case of myocardial infarction entered in the 3M Study between 1997 and 2000, we randomly selected two controls, matched for age (±3 years), from among the participants in risk factor surveys with no history of myocardial infarction. A total of 723 male employees (241 cases and 482 controls) aged 35 to 65 years were enrolled in the present study.<BR>Results: The subjects had significantly higher mean fasting LDL-cholesterol and triglyceride, and lower mean HDL-cholesterol than controls. The multivariable conditional odds ratio (95% confi-dence interval) for myocardial infarction after adjustment for known cardiovascular risk factors was 3.87 (1.27-11.7, p for trend <0.001) for total cholesterol [-6.71 vs <4.65 mmol/L], 3.28 (1.12-9.60, p for trend=0.001) for LDL-cholesterol [-4.64 vs <2.59 mmol/L], 0.17 (0.07-0.43, p for trend=0.001) for HDL-cholesterol [-1.55 vs <1.03 mmol/L] and 3.03 (1.37-6.70, p for trend= 0.01) for triglycerides [-2.26 vs <1.13 mmol/L].<BR>Conclusion: High total and LDL-cholesterol, low HDL-cholesterol and high triglycerides levels were independently associated with an increased risk of myocardial infarction among middle-aged Japa-nese male workers.

Journal

• Journal of Atherosclerosis and Thrombosis

  Journal of Atherosclerosis and Thrombosis 16 (6), 714-721, 2009

  Japan Atherosclerosis Society

Keywords

• LDL-cholesterol
• HDL-cholesterol
• Triglycerides
• Myocardial infarction
• Japanese

Details

• CRID: 1390282679408507904
• NII Article ID: 130004444339
• NII Article ID: 10026144002
• NII Book ID: AA11018976
• DOI: 10.5551/jat.547
• ISSN: 18803873
• ISSN: 13403478
• ISSN: http://id.crossref.org/issn/13403478
• Web Site: https://www.jstage.jst.go.jp/article/jat/16/6/16_547/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2010152990
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed