実験動物を用いた内耳細胞治療研究へのアプローチ

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  • Experimental Approaches to Inner Ear Cell Therapy Using Laboratory Animals
  • 動物実験を用いた内耳細胞治療研究へのアプローチ
  • ドウブツ ジッケン オ モチイタ ナイジ サイボウ チリョウ ケンキュウ エ ノ アプローチ

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Recently, a number of clinical studies on cell therapy have been reported and used in clinical practice for several intractable diseases. Inner ear cell therapy for sensorineural hearing loss also has been studied using some laboratory animals, although to date reports on successful hearing recovery have been few.<br> Previously, we developed a novel rat model of acute sensorineural hearing loss due to fibrocyte dysfunction induced by a mitochondrial toxin and performed cell therapy with bone marrow mesenchymal stem cells (MSCs). In this study, we injected MSCs into the lateral semicircular canal; a number of these stem cells were then detected in the injured area in the lateral wall. Rats with transplanted MSCs in the lateral wall demonstrated a significantly higher hearing recovery ratio than the untreated controls. These results suggested that mesenchymal stem cell transplantation into the inner ear may be a promising therapy for patients with sensorineural hearing loss due to degeneration of cochlear fibrocytes.<br> In this article, we review studies on inner ear cell therapy using some laboratory animals including rodents such as mice and rats, and primates such as cynomologus monkeys (Macaca fascicularis).<br>

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