Development of a Micro-Fluidic Device for Generating Concentration Gradient in the Flow Direction Using Diffusive Mixing of Droplets
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- Uzawa Shohei
- Department of Mechanical Engineering, Keio University
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- Ariga Keiji
- Department of Mechanical Engineering, Keio University
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- Miki Norihisa
- Department of Mechanical Engineering, Keio University
Bibliographic Information
- Other Title
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- 液滴の拡散混合を利用した流れ方向濃度グラジエント生成デバイスの開発
- エキテキ ノ カクサン コンゴウ オ リヨウ シタ ナガレ ホウコウ ノウド グラジエント セイセイ デバイス ノ カイハツ
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Abstract
Recently, micro total analysis system (μ-TAS) utilizing micro-fabricated fluidic components has been extensively studied. In the field of μ-TAS, one of the important techniques is generation of gradients. The concentration gradient is utilized in various fields, such as analytical chemistry, optics, and biology. A number of techniques that generate concentration gradient in a micro-channel have been reported, which focus on generating concentration gradient in the “width” direction. However, in some applications, such as HPLC in analytical chemistry, generating concentration gradient in the “flow” direction is mandatory. In this study, we propose a micro-fluidic device that generates concentration gradient in the flow direction using diffusive mixing of droplets. The device generates and handles droplets using surface-modification of micro-channels by self-assembled-monolayer (SAM). We designed, fabricated, and experimentally evaluated the concentration gradient generating device. We successfully demonstrated generation of the concentration gradient of acetonitrile. The results indicated that the proposed micro-fluidic device is readily applicable to the fields of analytical chemistry and biology.
Journal
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- IEEJ Transactions on Sensors and Micromachines
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IEEJ Transactions on Sensors and Micromachines 130 (2), 44-52, 2010
The Institute of Electrical Engineers of Japan
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Details 詳細情報について
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- CRID
- 1390001204459965184
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- NII Article ID
- 10026230861
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- NII Book ID
- AN1052634X
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- ISSN
- 13475525
- 13418939
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- NDL BIB ID
- 10568726
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed