Endogenous repair mechanisms in the brain

• Sawamoto Kazunobu

  Department of Developmental and Regenerative Biology, Nagoya City University Graduate School of Medical Sciences

Bibliographic Information

Other Title

• シンポジウム３‐３　中枢神経系の再生・次なる半世紀　脳に内在する神経再生機構
• 脳に内在する神経再生機構
• ノウ ニ ナイザイ スル シンケイ サイセイ キコウ

Abstract

Most of neurons are generated by neural stem cells in the developing brain at the embryonic or neonatal stages. However, recent studies indicate that adult brain also contains neural stem cells that continuously generate new neurons. Neurogenesis can be observed in the adult subventricular zone (SVZ) at the lateral wall of the lateral ventricles of various animal species including primates. Young neurons generated in the SVZ migrate over long distances and mature after they reach their final destinations where they function. In this talk, I will present our recent studies using animal models on the mechanisms of neuronal production, migration and maturation in the adult brain under physiological and pathological conditions, and discuss the possibility of their application into regeneration therapies for ischemic brain diseases.<br>

Journal

• Rinsho Shinkeigaku

  Rinsho Shinkeigaku 49 (11), 830-833, 2009

  Societas Neurologica Japonica

Keywords

• adult neurogenesis
• subventricular zone
• neural stem cell
• neuronal migration
• neuronal regeneration

Details

• CRID: 1390282680013170432
• NII Article ID: 10026290895
• NII Book ID: AN00253207
• DOI: 10.5692/clinicalneurol.49.830
• ISSN: 18820654
• ISSN: 0009918X
• NDL BIB ID: 10515601
• PubMed: 20030223
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10515601
• Web Site: https://search.jamas.or.jp/link/ui/2010076437
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed