Aggressive NK-cell leukemia with sustained relapse-free survival after allogeneic peripheral blood stem cell transplantation

• INO Kazuko

  Department of Internal Medicine, Matsusaka Chuo General Hospital Department of Hematology and Oncology, Mie University Graduate School of Medicine

• MASUYA Masahiro

  Department of Hematology and Oncology, Mie University Graduate School of Medicine

• NAKAMORI Yoshiki

  Department of Internal Medicine, Matsusaka Chuo General Hospital

• SUZUKI Kei

  Department of Hematology and Oncology, Mie University Graduate School of Medicine

• MIZUTANI Minoru

  Department of Internal Medicine, Matsusaka Chuo General Hospital

• SEKINE Takao

  Department of Internal Medicine, Matsusaka Chuo General Hospital

• YAMAGUCHI Motoko

  Department of Hematology and Oncology, Mie University Graduate School of Medicine

• NAKASE Kazunori

  Department of Hematology and Oncology, Mie University Graduate School of Medicine

• KAIDA Katsuji

  Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine

• OGAWA Hiroyasu

  Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine

• KATAYAMA Naoyuki

  Department of Hematology and Oncology, Mie University Graduate School of Medicine

Bibliographic Information

Other Title

• 同種末梢血幹細胞移植後長期間無再発生存中のアグレッシブNK細胞白血病
• 症例報告 同種末梢血幹細胞移植後長期間無再発生存中のアグレッシブNK細胞白血病
• ショウレイ ホウコク ドウシュ マッショウケツ カンサイボウ イショク ゴ チョウキカン ムサイハツ セイゾン チュウ ノ アグレッシブ NK サイボウ ハッケツビョウ

Abstract

A 46-year-old Japanese man was admitted to our hospital because of prolonged fever. Laboratory examination demonstrated leukopenia, thrombocytopenia, marked liver dysfunction, and elevation of serum ferritin. A bone marrow examination showed several hemophagocytic macrophages, and a diagnosis of hemophagocytic syndrome was made. He was treated using HLH-94 protocol, and his clinical symptoms and laboratory data were rapidly improved. After 5 weeks, fever and liver dysfunction reappeared. A repeat bone marrow examination demonstrated that 28.4% of marrow nucleated cells were atypical lymphocytes, which were positive for CD2, CD7, CD16, CD56, and HLA-DR. Clonality of these proliferating NK cells was confirmed by an analysis of EB virus terminal repeat sequence and cytogenetic analysis, and final diagnosis of aggressive NK-cell leukemia was made. After induction chemotherapy consisting of dexamethasone, etoposide, ifosfamide, and L-asparaginase, the patient achieved partial remission. He received allogeneic peripheral blood stem cell transplantation from his one locus mismatched son, and is alive with no evidence of disease 20 months after transplantation.

Journal

• Rinsho Ketsueki

  Rinsho Ketsueki 51 (4), 258-263, 2010

  The Japanese Society of Hematology

Keywords

• Aggressive NK-cell leukemia
• Epstein-Barr virus
• Hemophagocytic syndrome
• Allogeneic peripheral blood stem cell transplantation

Details

• CRID: 1390282680014095872
• NII Article ID: 10026332516
• NII Article ID: 130004501386
• NII Book ID: AN00252940
• DOI: 10.11406/rinketsu.51.258
• ISSN: 18820824
• ISSN: 04851439
• NDL BIB ID: 10691796
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10691796
• Web Site: https://search.jamas.or.jp/link/ui/2010178121
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed