Preparation of Hollow Fiber Immobilized Liposome Membrane

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  • Sugaya Hiroyuki
    Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University Specialty Materials Research Laboratories, Toray Industries, Inc.
  • Umakoshi Hiroshi
    Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University
  • Tohtaka Yuji
    Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University
  • Oyama Ena
    Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University
  • Shimanouchi Toshinori
    Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University
  • Kuboi Ryoichi
    Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University

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Abstract

Immobilized liposome membrane (ILM) was prepared in hollow fiber module (HF–ILM), where the liposome was loaded into the hollow fiber membrane module and was physically immobilized by forming the hydrogel in the cavity of the fiber membrane. Basic nature of the hydrogels prepared with xanthan gum (XG) and polyethyleneimine (PEI) via amino coupling method was first investigated in relation to the water contents of the gel matrix, so that the optimal condition for the liposome immobilization was obtained. The HF–ILM was prepared at the optimal condition, resulting in the high contents of immobilized liposome with high stability.

Journal

  • MEMBRANE

    MEMBRANE 34 (5), 272-280, 2009

    THE MEMBRANE SOCIETY OF JAPAN

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