ヒト関節リウマチにおけるTh17  [in Japanese] Th17 cells in human rheumatoid arthritis  [in Japanese]

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Author(s)

    • 山田 久方 YAMADA Hisakata
    • 九州大学生体防御医学研究所感染制御学分野 Division of Host Defense, Medical Institute of Bioregulation, Kyushu University

Abstract

  関節炎など自己免疫疾患動物モデルの多くは,Th1免疫反応により発症すると長年考えられてきたが,近年IL-17と,それを産生する新しいヘルパーCD4T細胞サブセットのTh17細胞がこれらの発症に重要なことが明らかとなってきた.ヒト関節リウマチ(RA)も同様にTh17細胞が重要な役割を担うと考えられるようになり,RA関節でのIL-17検出も報告されている.またIL-17の示す種々の生理活性はRAの関節破壊性病態を良く説明する.しかしRA患者において,実際どの程度Th17細胞が存在するのかは不明であった.そこで我々は細胞内染色フローサイトメーター法を用いてRAにおけるTh17細胞を解析したところ,末梢血中のTh17細胞数はRA患者と健常人の間に有意差を認めなかった.またTh17細胞数とRA疾患活動性との相関も認めなかった.さらに驚くべきことに,RA関節滑膜あるいは関節液中において,IFN-γを産生するTh1細胞は多数検出されるものの,Th17細胞はごく少数を認めるのみであった.他家の報告を見直しても,ヒトRA関節ではIL-17が大量に産生されているとは言い難いのが実際のようであった.ヒトRA病態へのTh17/IL-17の関与,重要性について結論付けるにはさらなる検討が必要と思われる.<br>

  Many autoimmune diseases, such as rheumatoid arthritis (RA), have been thought as Th1-mediated diseases. However, recent studies demonstrated critical roles of IL-17, which is produced by a newly identified subset of helper CD4T cells, Th17, in the development of murine models of autoimmune diseases. In addition, many biological functions of IL-17 fit very well with the pathology of RA joints. However, despite the presence of some reports detecting IL-17 in RA joints, the prevalence of Th17 cells in human RA had been largely unknown. Therefore, we analyzed Th17 cells in RA by intracellular staining methods. We found the frequency of IL-17-producing T cells was not increased in RA and was not correlated with disease activity of RA. Surprisingly, the frequency of CD4 T cells capable of IL-17 was decreased in the joints compared with PBL in each individual, whereas Th1 cells predominantly infiltrated in the joints. Taken together with the results of other reports measuring IL-17 production in RA, it seems premature to conclude that IL-17 is abundantly produced in RA joints. Further investigation on the involvement of Th17/IL-17 in human RA is required.<br>

Journal

  • Japanese Journal of Clinical Immunology

    Japanese Journal of Clinical Immunology 32(4), 249-255, 2009-08-31

    The Japan Society for Clinical Immunology

References:  40

Codes

  • NII Article ID (NAID)
    10026352183
  • NII NACSIS-CAT ID (NCID)
    AN00357971
  • Text Lang
    JPN
  • Article Type
    REV
  • ISSN
    09114300
  • Data Source
    CJP  J-STAGE 
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