Th17 cells in human rheumatoid arthritis
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- YAMADA Hisakata
- Division of Host Defense, Medical Institute of Bioregulation, Kyushu University
Bibliographic Information
- Other Title
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- ヒト関節リウマチにおけるTh17
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Abstract
Many autoimmune diseases, such as rheumatoid arthritis (RA), have been thought as Th1-mediated diseases. However, recent studies demonstrated critical roles of IL-17, which is produced by a newly identified subset of helper CD4T cells, Th17, in the development of murine models of autoimmune diseases. In addition, many biological functions of IL-17 fit very well with the pathology of RA joints. However, despite the presence of some reports detecting IL-17 in RA joints, the prevalence of Th17 cells in human RA had been largely unknown. Therefore, we analyzed Th17 cells in RA by intracellular staining methods. We found the frequency of IL-17-producing T cells was not increased in RA and was not correlated with disease activity of RA. Surprisingly, the frequency of CD4 T cells capable of IL-17 was decreased in the joints compared with PBL in each individual, whereas Th1 cells predominantly infiltrated in the joints. Taken together with the results of other reports measuring IL-17 production in RA, it seems premature to conclude that IL-17 is abundantly produced in RA joints. Further investigation on the involvement of Th17/IL-17 in human RA is required.<br>
Journal
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- Japanese Journal of Clinical Immunology
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Japanese Journal of Clinical Immunology 32 (4), 249-255, 2009
The Japan Society for Clinical Immunology
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Keywords
Details 詳細情報について
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- CRID
- 1390001204648976000
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- NII Article ID
- 10026352183
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- NII Book ID
- AN00357971
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- ISSN
- 13497413
- 09114300
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed