HTLV-1 and the Host Immune System : How the Virus Disrupts Immune Regulation, Leading to HTLV-1 Associated Diseases

• Satou Yorifumi

  Laboratory of Virus Control, Institute for Virus Research, Kyoto University

• Matsuoka Masao

  Laboratory of Virus Control, Institute for Virus Research, Kyoto University

抄録

Human T-cell leukemia virus type 1 (HTLV-1) was the first retrovirus shown to cause human diseases, such as adult T-cell leukemia (ATL) and HTLV-1 associated myelopathy/tropic spastic paraparesis (HAM/TSP). Despite extensive study for three decades, it remains elusive how HTLV-1 induces these diseases. HTLV-1 mainly infects CD4 T cells, inducing dysregulation of the host immune system. Recent studies have uncovered the mechanisms of differentiation and function of CD4 T cells at the cellular and molecular levels, extending our understanding of the pathological conditions associated with HTLV-1 infection. This review focuses on recent advances in our understanding of the interaction between HTLV-1 and the host immune system, which should provide us a clue to the mechanisms of HTLV-1 mediated pathogenesis. [J Clin Exp Hematopathol 50(1) : 1-8, 2010]

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　ａｎｄ　Ｅｘｐｅｒｉｍｅｎｔａｌ　Ｈｅｍａｔｏｐａｔｈｏｌｏｇｙ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｃｌｉｎｉｃａｌ　ａｎｄ　Ｅｘｐｅｒｉｍｅｎｔａｌ　Ｈｅｍａｔｏｐａｔｈｏｌｏｇｙ 50 (1), 1-8, 2010

  日本リンパ網内系学会

キーワード

• human T-cell leukemia virus type 1
• adult T-cell leukemia
• human T-cell leukemia virus type 1 bZIP factor
• chronic viral infection
• regulatory T cells

詳細情報

• CRID: 1390282679681960960
• NII論文ID: 10026387749
• NII書誌ID: AA11556796
• DOI: 10.3960/jslrt.50.1
• COI: 1:STN:280:DC%2BC3czmslyjuw%3D%3D
• ISSN: 18809952
• ISSN: 13464280
• PubMed: 20505271
• Web Site: https://search.jamas.or.jp/link/ui/2011039494
• 本文言語コード: en
• データソース種別:
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