ミクリッツ病に合併する嗅覚障害に関する検討

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  • A Clinical Study of Hyposmia Associated with Mikulicz's Disease

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Recent studies have differentiated Mikulicz's disease (MD) from Sjögren syndrome as immunoglobulin G4 (IgG4) systemic disease. We found that subjects with MD often report hyposmia, so we examined clinicopathological and serological findings in 38 subjects 14 men and 24 women with MD, analyzing cases of hyposmia. The mean IgG4 concentration (SD) in such cases was 950.5 (797.5) mg/dl. Of the 38, 16 (42%) had hyposmia, despite the absence of nasal cavity and sinus abnormalities such as obstructive and inflammatory disease. Dividing subjects into, hyposmia (+) and hyposmia (-) groups, we evaluated clinicopathological and serological findings, finding abundant IgG4-positive plasmacytes in the nasal mucosa of the hyposmia (+) group, but not in that of the hyposmia (-) group. We concluded that IgG4-positive plasmacyte infiltration may adversely affect in addition to nasal or/and Bowman's gland secretory activity in the olfactory epithelium in addition to the lacrimal and salivary glands.

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