Higher pAkt Expression Predicts a Significant Worse Prognosis in Glioblastomas

DOI PDF Web Site 被引用文献2件 参考文献55件
  • SUZUKI Yoshiyuki
    Department of Radiation Oncology, Gunma University Graduate School of Medicine
  • SHIRAI Katsuyuki
    Department of Radiation Oncology, Gunma University Graduate School of Medicine
  • OKA Kuniyuki
    Department of Pathology, Mito Saiseikai General Hospital
  • MOBARAKI Abdulelah
    Department of Radiation Oncology, Gunma University Graduate School of Medicine
  • YOSHIDA Yukari
    Department of Radiation Oncology, Gunma University Graduate School of Medicine
  • NODA Shin-ei
    Department of Radiation Oncology, Gunma University Graduate School of Medicine
  • OKAMOTO Masahiko
    Department of Radiation Oncology, Gunma University Graduate School of Medicine
  • SUZUKI Yoshihiko
    Division of Radiology, Takasaki National Hospital
  • ITOH Jun
    Section of Radiology, Maebashi Red Cross Hospital
  • ITOH Hideaki
    Section of Pathology, Maebashi Red Cross Hospital
  • ISHIUCHI Shogo
    Department of Neurosurgery, Faculty of Medicine, University of Ryukyus
  • NAKANO Takashi
    Department of Radiation Oncology, Gunma University Graduate School of Medicine

この論文をさがす

抄録

phosphorylated-Akt (pAkt) plays an important role in tumorigenesis through promotion of cell survival by inhibiting apoptosis and mediating cell proliferation. Higher expression of pAkt has been reported to be associated with an unfavorable prognosis in several malignant tumors. In this study, the prognostic value of pAkt expression was investigated in glioblastomas by using immunohistochemical methods. Tissue sections obtained from 64 patients with glioblastoma were evaluated. The mean and median follow-up period was 16.2 ± 12.4 and 12 months, respectively (range: from 1 to 62 months). pAkt expression levels were determined by immunohistochemical staining and evaluated for cell positivity. Positive staining was defined when more than 50% of the tumor cells were stained in each section. The correlation between expression of pAkt and overall survival rate was assessed. Glioblastomas showed either or both cytoplasmic and nuclear positive findings for pAkt. A total of 29.7% (19/64) of tissue specimens had greater than 50% positivity. The median survival periods of the patients with pAkt positive and negative tumor were 10 and 14 months, respectively. Two years overall survival rate of the pAkt positive and negative patients were 0% and 24.4%, respectively. Survival rate of the patients with pAkt positive tumor was significantly lower than that of the patients with pAkt negative tumors (p = 0.004). Multivariate analysis showed that extent of surgery was the strongest factor for survival (p = 0.01) and the pAkt expression was the secondly strongest factor (p = 0.06). These results suggest that the higher expression of pAkt the poorer prognosis in patients with glioblastoma.

収録刊行物

被引用文献 (2)*注記

もっと見る

参考文献 (55)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ