Enhanced Expression of the S100A8/A9 Complex in Acute Myocardial Infarction Patients

DOI Web Site 3 Citations 33 References
  • Katashima Takashi
    Department of Internal Medicine III, Osaka Medical College
  • Naruko Takahiko
    Department of Cardiology, Osaka City General Hospital
  • Terasaki Fumio
    Department of Internal Medicine III, Osaka Medical College
  • Fujita Masatoshi
    Human Health Sciences, Kyoto University Graduate School of Medicine
  • Otsuka Kaoru
    Department of Internal Medicine III, Osaka Medical College
  • Murakami Shougo
    Department of Internal Medicine III, Osaka Medical College
  • Sato Akira
    Department of Cardiology, University of Tsukuba Graduate School of Comprehensive Human Science
  • Hiroe Michiaki
    Department of Cardiology, International Medical Center of Japan
  • Ikura Yoshihiro
    Department of Pathology, Osaka City University Graduate School of Medicine
  • Ueda Makiko
    Department of Pathology, Osaka City University Graduate School of Medicine
  • Ikemoto Masaki
    Human Health Sciences, Kyoto University Graduate School of Medicine
  • Kitaura Yasushi
    Department of Internal Medicine III, Osaka Medical College

Search this article

Abstract

Background: S100A8/A9 complex (S100A8/A9) is expressed in activated human neutrophils and macrophages. Enhanced expression of S100A8/A9 in atherosclerotic plaque of patients with unstable angina pectoris (UAP) has been demonstrated, but its profile in acute myocardial infarction (AMI) has not been clarified. Methods and Results: Serum S100A8/A9 levels were serially measured in patients with AMI (n=55) and UAP (n=16) during the acute period. The expression of S100A8/A9 was examined immunohistochemically in the infarcted myocardium of 7 autopsied patients with AMI. Serum S100A8/A9 levels on the 1st day were 1,118±115 (SE) ng/ml in AMI patients as compared with 787±147 ng/ml in UAP patients. On days 3-5, serum S100A8/A9 levels in AMI patients reached a peak value and were significantly higher than the values in UAP patients (1,690±144 ng/ml vs 844±100 ng/ml; P<0.0001). In AMI patients, peak S100A8/A9 levels positively correlated with peak white blood cell and neutrophil counts, and peak creatine kinase-MB and peak C-reactive protein levels. Double immunostaining revealed that S100A8/A9 was specifically expressed in neutrophils and macrophages infiltrating the infarcted myocardium. Conclusions: S100A8/A9 is implicated in the pathophysiology of AMI and may be an additional biomarker of the local inflammatory response following AMI. (Circ J 2010; 74: 741-748)<br>

Journal

  • Circulation Journal

    Circulation Journal 74 (4), 741-748, 2010

    The Japanese Circulation Society

Citations (3)*help

See more

References(33)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top