Relationship Between Renal Dysfunction and Severity of Coronary Artery Disease in Japanese Patients

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  • Kiyosue Arihiro
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
  • Hirata Yasunobu
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
  • Ando Jiro
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
  • Fujita Hideo
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
  • Morita Toshihiro
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
  • Takahashi Masao
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
  • Nagata Daisuke
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
  • Kohro Takahide
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
  • Imai Yasushi
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo
  • Nagai Ryozo
    Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo

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Abstract

Background: The relationship between renal dysfunction and the severity of coronary artery disease (CAD) was examined. Methods and Results: The severity of CAD in 572 patients was graded according to the number of stenotic coronary arteries, and the estimated glomerular filtration rate (eGFR) was monitored for 3 years. Patients were stratified into 3 eGFR groups: normal (>75 ml · min-1 · 1.73 m-2), mild reduction (60-75) and chronic kidney disease (CKD: <60). There were 161 patients in the CKD group. The average number of stenotic coronary arteries was larger in the CKD group than in the other groups (normal vs mild reduction vs CKD =1.35±0.07 (SE) vs 1.22±0.08 vs 1.69±0.08 vessel disease (VD), P<0.001). During the 3-year follow-up, the renal function of 13.8% of the patients worsened. Those who showed more deterioration of eGFR had more severe CAD than those who did not (1.20±0.06 vs 1.61±0.06 VD, P<0.001). Multivariate analysis revealed that the severity of CAD was independently and significantly associated with the deterioration of eGFR. Conclusions: Patients with CKD had more severe CAD, which may explain the high rate of cardiovascular events in these patients. Moreover, the prognosis of renal function was poor in patients with severe CAD, and CAD was found to be an independent risk factor for worsening of renal dysfunction. (Circ J 2010; 74: 786-791)<br>

Journal

  • Circulation Journal

    Circulation Journal 74 (4), 786-791, 2010

    The Japanese Circulation Society

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