Stromal Cell Biology - A Way to Understand the Evolution of Cardiovascular Diseases -
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- Tsuruda Toshihiro
- Department of Internal Medicine, Circulatory and Body Fluid Regulation, University of Miyazaki
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- Imamura Takuroh
- Department of Internal Medicine, Circulatory and Body Fluid Regulation, University of Miyazaki
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- Hatakeyama Kinta
- Department of Pathology, Faculty of Medicine, University of Miyazaki
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- Asada Yujiro
- Department of Pathology, Faculty of Medicine, University of Miyazaki
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- Kitamura Kazuo
- Department of Internal Medicine, Circulatory and Body Fluid Regulation, University of Miyazaki
Bibliographic Information
- Other Title
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- Stromal cell biology—a way to understand the evolution of cardiovascular diseases
- – A Way to Understand the Evolution of Cardiovascular Diseases –
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Abstract
Stromal cells, composed of fibroblasts, microvascular endothelial cells, immune cells and inflammatory cells, are critical determinants of the mechanical properties and function of the heart and vasculature, and the mechanisms whereby these types of cells are activated are important to understand the progression of cardiovascular diseases. Emerging studies have suggested that the activation of autocrine and paracrine signaling pathways by stromal cell-derived growth factors, cytokines and bioactive molecules contributes to disease progression. Disruption of the stromal network will result in alterations in the geometry and function in these organs. Interventions targeting the stromal cells (eg, myofibroblasts, microvascular endothelial cells, inflammatory cells) by pharmacological agents or direct gene delivery/small interfering RNA would be potential novel therapeutic strategies to prevent/attenuate the progression of cardiovascular disorders. (Circ J 2010; 74: 1042 - 1050)<br>
Journal
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- Circulation Journal
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Circulation Journal 74 (6), 1042-1050, 2010
The Japanese Circulation Society
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Details 詳細情報について
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- CRID
- 1390001205102328704
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- NII Article ID
- 10026474117
- 130000247796
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- NII Book ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed