Visceral Fat Is a Strong Predictor of Insulin Resistance Regardless of Cardiorespiratory Fitness in Non-Diabetic People

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Author(s)

Abstract

Abdominal adiposity and low cardiorespiratory fitness are assosicated with insulin resistance in people with impaired glucose tolerance and type 2 diabetes. However, little is known about which factor precedes insulin resistance in people with impaired glucose tolerance and type 2 diabetes, and which is the stronger predictor of insulin resistance in non-diabetic people. The purpose of this study was to examine the relationship between insulin resistance and cardiorespiratory fitness, visceral fat, and subcutaneous fat in non-diabetic people. Subjects included 87 men and 77 women aged 30-72 y (mean±SD, 51.3±12.3 y). Cardiorespiratory fitness was assessed by measuring the maximal oxygen uptake (V<small>O</small><sub>2max</sub>) in a progressive continuous test to exhaustion on a cycle ergometer. The visceral and subcutaneous fat areas were measured by magnetic resonance imaging. The homeostasis model assessment of insulin resistance (HOMA-R) was calculated from the fasting concentrations of glucose and insulin. Stepwise multiple linear regression analysis revealed that visceral and subcutaneous fat were significant correlates of HOMA-R, explaining 24% and 6% of the variance, respectively, whereas sex, age, and V<small>O</small><sub>2max</sub> were not significant independent determinants. Abdominal fat deposition rather than cardiorespiratory fitness is a significant predictor of insulin resistance in non-diabetic people; visceral fat is the most important factor.

Journal

  • Journal of Nutritional Science and Vitaminology

    Journal of Nutritional Science and Vitaminology 56(2), 109-116, 2010-04-01

    Center for Academic Publications Japan

References:  21

Cited by:  1

Codes

  • NII Article ID (NAID)
    10026476636
  • NII NACSIS-CAT ID (NCID)
    AA00703822
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    03014800
  • NDL Article ID
    10652555
  • NDL Source Classification
    ZR2(科学技術--生物学--生化学)
  • NDL Call No.
    Z53-B484
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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