Application of Decoy Oligodeoxynucleotides for Arthritis

• Tomita Tetsuya

  Department of Orthopaedics, Osaka University Graduate School of Medicine

• Kunugiza Yasuo

  Department of Orthopaedics, Osaka University Graduate School of Medicine Division of Clinical Gene Therapy, Osaka University Graduate School of Medicine

• Tomita Naruya

  Division of Nephrology, Department of Internal Medicine, Kawasaki Medical School

• Kuroda Shoko

  Department of Orthopaedics, Osaka University Graduate School of Medicine Division of Clinical Gene Therapy, Osaka University Graduate School of Medicine

• Morishita Ryuichi

  Division of Clinical Gene Therapy, Osaka University Graduate School of Medicine

• Yoshikawa Hideki

  Department of Orthopaedics, Osaka University Graduate School of Medicine

抄録

Recent progress in DNA technologies has provided the strategies to regulate the transcription of disease-related genes in vivo using antisense oligodeoxynucleotide (ODN). Transfection of cis-element double-stranded oligodeoxynucleotides (decoy ODNs) has been reported as a new therapeutic tool of anti-gene strategies for gene therapy. In the field of arthritis, decoy ODNs strategies have been significant therapeutic potential. The concept of regulation the disease related gene expression at the level of transcriptional factor may be more therapeutic effects compared with monotherapy in arthritis.

収録刊行物

• Inflammation and Regeneration

  Inflammation and Regeneration 26 (6), 507-512, 2006

  一般社団法人 日本炎症・再生医学会

キーワード

• arthritis
• decoy oligodeoxynucleotides
• NFκB
• E2F
• osteoclast

詳細情報

• CRID: 1390282680234018688
• NII論文ID: 10026499883
• NII書誌ID: AA11508953
• DOI: 10.2492/inflammregen.26.507
• ISSN: 18808190
• ISSN: 18809693
• NDL書誌ID: 8685316
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8685316
• Web Site: https://search.jamas.or.jp/link/ui/2007174390
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可