ペグインターフェロン治療における診療アクセスの改善策に関する多施設共同研究 : 前向き研究と後ろ向き研究からの考察  [in Japanese] Multi-center clinical studies for strategies to improve patients' accessibility to peginterferon therapy : Consideration based on both prospective study and retrospective study  [in Japanese]

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Abstract

ペグインターフェロン治療における診療アクセス改善策としての外来導入推進の是非を明らかにするために,全国14施設による臨床研究を行なった.ペグインターフェロン治療を終了し治療効果判定可能な879例を対象とした後ろ向き研究では,入院導入と外来導入とで薬剤アドヒアランスやウイルス学的治療効果に有意差はなく,かつ,有害事象等での中止率はむしろ後者の方が低い傾向にあることが明らかとなった.さらに,前向き研究として,新規にペグインターフェロン(・リバビリン併用)療法を導入する患者を対象とした無記名アンケート調査を行なったところ(111例,入院:外来=1:2),入院導入患者の約60%が「入院期間の短縮ないし外来導入」を希望し,外来導入患者の約80%が「外来導入でよかった」と回答した.現行のペグインターフェロン(・リバビリン併用)療法は消化器,肝臓の専門医が関与すれば外来導入でも十分安全に施行しうると考えられた.<br>

To evaluate whether start-up of peginterferon therapy for chronic hepatitis C at out-patient clinic may improve patients' accessibility, multi-center clinical studies were performed. In retrospective study with 879 patients who had already finished peginterferon (plus ribavirin) therapy, adherence to treatment regimen and final virological response were quite similar in both modes of start-up (at hospitalization or at out-patient clinic). In addition, interruption rate was rather lower in patients with start-up at out-patient clinic than in those at hospitalization. In prospective study, unsigned questionnaires about modes of start-up were carried out. Twenty-two out of 38 (58%) patients who started up peginterferon therapy at hospitalization preferred shorter hospital stays or start-up at out-patient clinic. In contrast, fifty-nine out of 73 (81%) patients who started up at out-patient clinic were completely satisfied. These lines of evidence may suggest start-up at out-patient clinic is fully safe and improves patients' accessibility to peginterferon therapy.<br>

Journal

  • Kanzo

    Kanzo 51(7), 348-360, 2010-07-25

    The Japan Society of Hepatology

References:  4

Cited by:  2

Codes

  • NII Article ID (NAID)
    10026515271
  • NII NACSIS-CAT ID (NCID)
    AN00047770
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    04514203
  • NDL Article ID
    10766040
  • NDL Source Classification
    ZS21(科学技術--医学--内科学)
  • NDL Call No.
    Z19-130
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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