生体分子の動態を捉える高速原子間力顕微鏡  [in Japanese] High-speed Atomic Force Microscopy for Capturing Dynamic Behavior of Biological Molecules  [in Japanese]

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Author(s)

Abstract

The function of proteins is engendered through their dynamic structural changes and dynamic interactions with other molecules. Although their direct real-space and real-time visualization is a straightforward approach to understanding the dynamic molecular processes, the lack of techniques has precluded it. Atomic force microscopy (AFM) is a versatile technique to image proteins in liquids at sub-molecular resolution, but its poor temporal resolution has meant an availability of only static or slow time-lapse images of proteins. Recently, this situation is, however, quickly changing. Over the past 15 years, studies toward increasing the scan speed of AFM and making high-speed imaging compatible with low-invasive imaging have been carried out at my lab. As a result, high-speed imaging, which is 1000 times faster than before, is achieved. This report presents exemplification of dynamic imaging of functioning biological samples.

Journal

  • Hyomen Kagaku

    Hyomen Kagaku 31(8), 405-410, 2010-08-10

    The Surface Science Society of Japan

References:  28

Codes

  • NII Article ID (NAID)
    10026546073
  • NII NACSIS-CAT ID (NCID)
    AN00334149
  • Text Lang
    JPN
  • Article Type
    ART
  • ISSN
    03885321
  • NDL Article ID
    10805033
  • NDL Source Classification
    ZM35(科学技術--物理学)
  • NDL Call No.
    Z15-379
  • Data Source
    CJP  NDL  J-STAGE 
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