Symptomatic Hypersomnia Due to Orexin Deficiency in Hypothalamic Lesions
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- Kanbayashi Takashi
- Departments of Psychiatry Akita University School of Medicine
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- Arii Junko
- Department of Pediatrics, Chiba University School of Medicine
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- Kubota Hiroaki
- Department of Pediatrics, Chiba University School of Medicine
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- Yano Tamami
- Department of Pediatrics, Akita University School of Medicine
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- Kashiwagi Mitsuru
- Department of Pediatrics, Osaka Medical College
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- Yoshikawa Sousuke
- Department of Pediatrics, Osaka Medical College
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- Tohyama Jun
- Epilepsy Center, National Nishi-Niigata Chuo Hospital
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- Sawaishi Yukio
- Department of Pediatrics, Akita University School of Medicine
Bibliographic Information
- Other Title
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- 視床下部病変によりオレキシン神経障害を来した2次性過眠症8例の検討
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Abstract
Narcolepsy is characterized by excessive daytime sleepiness (EDS), cataplexy and other abnormal manifestations of REM sleep. Recently, it was discovered that the pathophysiology of idiopathic narcolepsy-cataplexy is linked to orexin ligand deficiency in the brain and cerebrospinal fluid. Orexin neurons localize in the posterior hypothalamic area, which was previously described as “waking center” by von Economo in 1920s. Hypersomnia due to orexin ligand deficiency can also occur during the course of other neurological conditions, such as hypothalamic tumor, encephalopathy and demyelinating disorder (i.e. symptomatic hypersomnia). We experienced 8 pediatric cases with symptomatic hypersomnia. These cases were diagnosed as brain tumor (n=2), head trauma (n=1), encephalopathy (n=1), demyelinating disorder (n=3) and infarction (n=1). Six pediatric cases with orexin measurements from the literatures were additionally included and total 14 cases were studied. Although it is difficult to rule out the comorbidity of idiopathic narcolepsy insome cases, a review of the case histories reveals numerous unquestionable cases of symptomatic hypersomnia. In these cases, the occurrences ofthe hypersomnia run parallel with the rise and fall of the causative diseases. Most of symptomatic hypersomnia cases show both extended nocturnal sleep time and EDS consisting of prolonged sleep episodes of NREM sleep. The features of nocturnal sleep and EDS in symptomatic hypersomnia are more similar to idiopathic hypersomnia than to narcolepsy.
Journal
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- NO TO HATATSU
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NO TO HATATSU 38 (5), 340-345, 2006
THE JAPANESE SOCIETY OF CHILD NEUROLOGY
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Details 詳細情報について
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- CRID
- 1390282679531229440
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- NII Article ID
- 10026611437
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- NII Book ID
- AN0020232X
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- ISSN
- 18847668
- 00290831
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- PubMed
- 16986734
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- Text Lang
- ja
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- Data Source
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- JaLC
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed