The Role of Integrins in the Human Reproductive Process.

• YOSHIMURA Yasunori

  Department of Obstetrics and Gynecology, Keio University School of Medicine

Bibliographic Information

Other Title

• Role of Integrins in the Human Reproductive Process

Abstract

Integrins are heterodimeric transmembrane glycoproteins involved in cell-cell and cell-extracellular matrix adhesion. They also participate in cytoskeletal rearrangement, co-regulation of growth factor activities and activation of signal transduction. This review describes the available information regarding the role of integrins in human reproductive physiology and discusses their clinical implications. Integrins play important roles in several reproductive processes including fertilization, embryogenesis, and implantation. Disturbance of integrin expression in reproductive organs can be the cause, or the result of such reproductive disorders as endometriosis, unexplained infertility, hydrosalpinx, ectopic pregnancy, and preeclampsia. Further knowledge of the integrin-mediated regulation of cell growth and cell survival may facilitate our understanding of many key aspects of development and physiology in reproduction.

Journal

• Journal of Reproduction and Development

  Journal of Reproduction and Development 48 (3), 215-232, 2002

  The Society for Reproduction and Development

Keywords

• Integrin
• Fertilization
• Embryogenesis
• Implantation
• Infertility

Details

• CRID: 1390282681314465792
• NII Article ID: 10026616395
• NII Book ID: AA10936678
• DOI: 10.1262/jrd.48.215
• COI: 1:CAS:528:DC%2BD38XmvFSmtr8%3D
• ISSN: 13484400
• ISSN: 09168818
• NDL BIB ID: 6206120
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I6206120
• Web Site: http://www.jstage.jst.go.jp/article/jrd/48/3/48_3_215/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2003053688
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed