卵巣機能調節機構における腫瘍壊死因子の生理的役割

  • SAKUMOTO Ryosuke
    Department of Physiology and Genetic Regulation, National Institute of Agrobiological Sciences
  • OKUDA Kiyoshi
    Laboratory of Reproductive Endocrinology, Faculty of Agriculture, Okayama University

書誌事項

タイトル別名
  • Possible Actions of Tumor Necrosis Factor-.ALPHA. in Ovarian Function
  • JSAR Young Investigator Award: Possible Actions of Tumor Necrosis Factor-α in Ovarian Function
  • JSAR Young Investigator Award Possible Actions of Tumor Necrosis Factor アルファ in Ovarian Function

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抄録

Tumor necrosis factor-α (TNFα) is a multifunctional cytokine that was first described as a tumoricidal factor produced by activated macrophages. Extensive research over the last two decades has suggested that TNFα has physiologically diverse actions in ovarian function in a variety of species. TNFα and its specific receptors are present in the ovaries of many species. Furthermore, TNFα plays multiple and probably important roles in corpus luteum (CL) function as well as ovarian cell function throughout the estrous cycle. This review focuses on recent studies documenting TNFα in ovarian follicles and CL in several mammals. In addition, possible roles of TNFα in ovarian function throughout the estrous cycle and in the gestation period are discussed.<br>

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