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- TAMURA Mariko
- Gene Research Center, University of Tsukuba
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- NAKAGAWA Yosimi
- Gene Research Center, University of Tsukuba
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- SHIMIZU Hidehisa
- Gene Research Center, University of Tsukuba
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- YAMADA Noriaki
- Gene Research Center, University of Tsukuba
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- MIYANO Takashi
- Graduate School of Science and Technology and Faculty of Agriculture, Kobe University
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- MIYAZAKI Hitoshi
- Gene Research Center, University of Tsukuba
書誌事項
- タイトル別名
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- Cellular Functions of Mitogen-activated Protein Kinases and Protein Tyrosine Phosphatases in Ovarian Granulosa Cells
- JSAR Outstanding Presentation Award: Cellular Functions of Mitogen-activated Protein Kinases and Protein Tyrosine Phosphatases in Ovarian Granulosa Cells
この論文をさがす
抄録
A number of endocrine and paracrine factors regulate the follicular growth and atresia, which are closely associated with granulosa cell survival and apoptosis. However, the molecular mechanisms underlying the intracellular events induced by these factors are poorly understood. Here, we describe the correlation of mitogen-activated protein kinase (MAPK) activities with granulosa cell survival and apoptosis, and the cellular functions of protein tyrosine phosphatases (PTPs) in these cells based on our recent data. MAPKs play key roles in various cellular responses because numerous extracellular stimuli are integrated into MAPKs. The protein phospho-Tyr level regulated by protein tyrosine kinases (PTKs) and PTPs is a major control mechanism for processes as diverse as cell survival, proliferation, differentiation, and metabolism. Although PTKs are critically involved in granulosa cell survival and proliferation, there are no reports indicating the roles of PTPs in the ovary except for ours. Information about MAPKs and PTPs in these cells will provide a basis for the understanding of the molecular mechanisms controlling the fate of follicles.<br>
収録刊行物
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- Journal of Reproduction and Development
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Journal of Reproduction and Development 50 (1), 47-55, 2004
公益社団法人 日本繁殖生物学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390282681314284160
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- NII論文ID
- 10026620927
- 130000054839
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- NII書誌ID
- AA10936678
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- ISSN
- 13484400
- 09168818
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- NDL書誌ID
- 6867373
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- PubMed
- 15007201
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可