Effect of 0.1% Tacrolimus Ointment in the Treatment of Adult Patients with Atopic Dermatitis on the Trunk and Limbs

DOI Web Site 18 References

Bibliographic Information

Other Title
  • 成人アトピー性皮膚炎躯幹・四肢に対する０．１％タクロリムス軟膏の効果
  • 治療 成人アトピー性皮膚炎躯幹・四肢に対する0.1%タクロリムス軟膏の効果
  • チリョウ セイジン アトピーセイ ヒフエン クカン シシ ニ タイスル 0 1パーセント タクロリムス ナンコウ ノ コウカ

Search this article

Abstract

The potential efficacy and safety of 0.1% tacrolimus ointment for the treatment of atopic dermatitis on the trunk and limbs were evaluated in a 24-week, open-label, non-comparative study that included 104 adult patients. Investigated scores for erythema and papule were significantly decreased during the first 2 weeks of therapy and continuous improvement was observed throughout the study. The pruritus score was also decreased significantly at 2 weeks and the improvement was continued throughout the study. Prurigo and lichenification scores were significantly decreased at 24 weeks, although the decrease was gradual. As to adverse events, transient skin burning was observed in 20% of patients during the study period. Three patients were removed from the study because of skin infection (2 cases) and skin burning (1 case). These results suggest that 0.1% tacrolimus ointment is safe and effective as long-term treatment of adult patients with atopic dermatitis on the trunk and limbs.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 68 (6), 671-676, 2006

    Western Division of Japanese Dermatological Association

References(18)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top