A Case of Dermatomyositis with Skin Ulcers

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  • KUWATSUKA Yutaka
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences
  • MINE Yoshikazu
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences
  • OGAWA Fumihide
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences
  • TAKENAKA Motoi
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences
  • SATO Shinichi
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences
  • ISHIKAWA Hiroshi
    Division of Dermatology, National Hospital Organization Nagasaki Medical Center
  • SHUKUWA Tetsuo
    Division of Dermatology, National Hospital Organization Nagasaki Medical Center

Bibliographic Information

Other Title
  • 皮膚潰瘍を伴った皮膚筋炎の１例
  • 症例 皮膚潰瘍を伴った皮膚筋炎の1例
  • ショウレイ ヒフ カイヨウ オ トモナッタ ヒフ キンエン ノ 1レイ

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Abstract

We report a 47-year old male patient who had dermatomyositis with skin ulcers. He had swollen fingers with erythema and arthralgia 9 months before visiting our hospital. Having suspected collagen disease at a former clinic, daily oral prednisolone of 12 mg/day was administered without any symptom improvement. In addition, skin ulcers of dorsal manus and back, muscle weakness, and dyspnea on exertion gradually developed in the patient. In December, 2005, he visited our hospital, and dermatomyositis was diagnosed according to the presence of the heliotrope rashes, Gottron’s signs, and his histological findings of skin lesions. Chest computed tomography and echocardiography revealed interstitial pneumonia and mild pulmonary hypertension. After a steroid pulse therapy, oral predonisolone of 60 mg/day was administered in combination with oral cyclosporine A 200mg/day and beraprost sodium. Skin ulcers were managed by topical basic fibroblast growth factor and prostaglandin E1 ointments. Pulmonary hypertension was also managed by beraprost sodium. Although therapeutic responses of interstitial pneumonia and pulmonary hypertension were relatively good and rapid, the complete healing of skin ulcers required about 7 month’s treatment. No malignant tumors could be found.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 69 (6), 605-609, 2007

    Western Division of Japanese Dermatological Association

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