Efficacy of Maxacalcitol Lotion in Place of Other Topically Applied Lotions for Psoriasis Vulgaris of the Scalp

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  • MORITA Akimichi
    Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences
  • MAEDA Akira
    Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences
  • FURUHASHI Takuya
    Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences
  • KAWASHIMA Kana
    Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences
  • ITO Toshihiro
    Department of Dermatology, The Jikei University, School of Medicine
  • FUKUCHI Osamu
    Department of Dermatology, The Jikei University, School of Medicine
  • NAKAGAWA Hidemi
    Department of Dermatology, The Jikei University, School of Medicine
  • ENDOH Kouki
    Department of Dermatology, The Iwate Medical University, School of Medicine
  • WATABE Daisuke
    Department of Dermatology, The Iwate Medical University, School of Medicine
  • AKASAKA Toshihide
    Department of Dermatology, The Iwate Medical University, School of Medicine
  • SUGAI Junichi
    Department of Dermatology, Jichi Medical University
  • KOMINE Mayumi
    Department of Dermatology, Jichi Medical University
  • HIRASHIMA Miho
    Department of Dermatology, Jichi Medical University
  • OHTSUKI Mamitaro
    Department of Dermatology, Jichi Medical University

Bibliographic Information

Other Title
  • 被髪頭部の尋常性乾癬に外用中のローションからマキサカルシトールローションへの切り替えの有用性
  • 治療 被髪頭部の尋常性乾癬に外用中のローションからマキサカルシトールローションへの切り替えの有用性
  • チリョウ ヒカミガシラブ ノ ジンジョウセイカンセン ニ ガイヨウ チュウ ノ ローション カラ マキサカルシトールローション エ ノ キリカエ ノ ユウヨウセイ

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Abstract

Forty-five patients with psoriasis vulgaris of the scalp who had used topical tacalcitol lotions (high or low concentration) or topical steroid lotions for the treatment of skin eruptions were enrolled in this study. The patients had previously used high-concentration tacalcitol lotion (19 patients), low-concentration tacalcitol lotion (1 patient), and/or steroid lotions (very potent : 23 patients; mildly or moderately potent : 8 patients). The efficacy, safety, and usefulness of topical maxacalcitol lotion (Oxarol® Lotion 25 μg/g) were evaluated. Efficacy: scores for erythema, infiltration/thickening, scale formation, and the total of these three scores were significantly decreased at weeks 4 and 8 (Wilcoxon signed-rank test, p<0.001). Safety : local side effects were observed in 2 patients, but no systemic side effects were observed. Usefulnes : 87.2% of the patients rated it as “very effective” or “effective”. In conclusion, topical maxacalcitol lotion was highly effective without any adverse effects when used as a replacement for other topical lotions, including high- and low-concentration tacalcitol lotion and steroid lotions. Maxacalcitol lotion is a highly effective treatment for psoriasis vulgaris on the scalp.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 72 (4), 397-404, 2010

    Western Division of Japanese Dermatological Association

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