Intravenous Methylprednisolone Reduces the Risk of Propofol-Induced Adverse Effects During Wada Testing
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- MIKUNI Nobuhiro
- Department of Neurosurgery, Kyoto University Graduate School of Medicine
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- YOKOYAMA Youhei
- Department of Neurosurgery, Kyoto University Graduate School of Medicine
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- MATSUMOTO Atsuhito
- Department of Neurosurgery, Kyoto University Graduate School of Medicine
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- KIKUCHI Takayuki
- Department of Neurosurgery, Kyoto University Graduate School of Medicine
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- YAMADA Shigeki
- Department of Neurosurgery, Kyoto University Graduate School of Medicine
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- HASHIMOTO Nobuo
- National Cerebral and Cardiovascular Center
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- MIYAMOTO Susumu
- Department of Neurosurgery, Kyoto University Graduate School of Medicine
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Abstract
The adverse effects and risks associated with intracarotid propofol injection during Wada testing were retrospectively compared in two groups of patients with (n = 75) and without (n = 58) intravenous methylprednisolone administered before intracarotid propofol injection. The incidences of all adverse effects were decreased in the methylprednisolone group. In particular, severe adverse effects such as increased muscle tone with twitching and rhythmic movements or tonic posture, which could adversely affect Wada test results, were seen in one patient in the methylprednisolone group and seven patients in the control group, indicating 92% risk reduction. This study suggests that Wada testing using intravenous methylprednisolone administration prior to propofol injection is a safe approach to the preoperative evaluation of brain tumors, epilepsy, and arteriovenous malformations.<br>
Journal
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- Neurologia medico-chirurgica
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Neurologia medico-chirurgica 50 (8), 622-626, 2010
The Japan Neurosurgical Society
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Details 詳細情報について
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- CRID
- 1390282680032582784
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- NII Article ID
- 10026651242
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- NII Book ID
- AN00358613
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- ISSN
- 13498029
- 04708105
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed