Brain Metastasis of Undifferentiated Sarcoma and Response to Temozolomide Treatment -Case Report-

• TANAKA Hirotomo

  Department of Neurosurgery, Kobe University Graduate School of Medicine

• SASAYAMA Takashi

  Department of Neurosurgery, Kobe University Graduate School of Medicine

• NISHIHARA Masamitsu

  Department of Neurosurgery, Kobe University Graduate School of Medicine

• ARAI Atsushi

  Department of Neurosurgery, Kobe University Graduate School of Medicine

• KAWAMURA Atsufumi

  Department of Neurosurgery, Hyogo Prefectural Kobe Children's Hospital

• KANOMATA Naoki

  Department of Pathology, Kobe University Graduate School of Medicine

• ITOH Tomoo

  Department of Pathology, Kobe University Graduate School of Medicine

• KOHMURA Eiji

  Department of Neurosurgery, Kobe University Graduate School of Medicine

Bibliographic Information

Other Title

• —Case Report—

Abstract

A 33-year-old woman presented with rare brain metastases from undifferentiated high-grade sarcoma manifesting as headache and vomiting. Magnetic resonance (MR) imaging demonstrated multiple tumors in the brain, subcutaneous soft tissue, and mediastinum. The patient underwent surgery, followed by chemotherapy and radiotherapy. The histological diagnosis was undifferentiated high-grade sarcoma. Radiotherapy was effective, but the brain tumors recurred 6 months later. The patient underwent high-dose methotrexate therapy, but showed no response. Promoter hypermethylation in the O⁶-methylguanine-deoxyribonucleic acid methyltransferase (MGMT) genes was detected and MGMT protein expression was negative in the recurrent tumor, so temozolomide (TMZ) salvage chemotherapy was given, and follow-up MR imaging showed tumor reduction. This case suggests that TMZ may be effective for brain metastasis of undifferentiated sarcoma without MGMT protein expression.<br>

Journal

• Neurologia medico-chirurgica

  Neurologia medico-chirurgica 50 (8), 689-693, 2010

  The Japan Neurosurgical Society

Keywords

• undifferentiated sarcoma
• brain metastasis
• temozolomide
• O⁶-methylguanine-deoxyribonucleic acid methyltransferase

Details

• CRID: 1390001205055811584
• NII Article ID: 10026651567
• NII Book ID: AN00358613
• DOI: 10.2176/nmc.50.689
• ISSN: 13498029
• ISSN: 04708105
• Web Site: http://www.jstage.jst.go.jp/article/nmc/50/8/50_8_689/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2011080098
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed