Prenatal exposure to titanium dioxide nanoparticles increases dopamine levels in the prefrontal cortex and neostriatum of mice

• Takahashi Yuta

  Department of Hygiene Chemistry, Faculty of Pharmaceutical Science, Tokyo University of Science

• Mizuo Keisuke

  Research Center for Health Science of Nanoparticles, Research Institute for Science and Technology, Tokyo University of Science Department of Legal Medicine and Molecular Alcohology, Sapporo Medical University School of Medicine

• Shinkai Yusuke

  Research Center for Health Science of Nanoparticles, Research Institute for Science and Technology, Tokyo University of Science

• Oshio Shigeru

  Research Center for Health Science of Nanoparticles, Research Institute for Science and Technology, Tokyo University of Science Department of Hygiene Chemistry, Ohu University School of Pharmaceutical Sciences

• Takeda Ken

  Department of Hygiene Chemistry, Faculty of Pharmaceutical Science, Tokyo University of Science Research Center for Health Science of Nanoparticles, Research Institute for Science and Technology, Tokyo University of Science

Abstract

Titanium dioxide (TiO₂) nanoparticles are widely used in cosmetics, sunscreen and as a photocatalyst. However, little is known about the biological effect of TiO₂ nanoparticles in humans and other animals. Here, we investigated whether prenatal exposure to TiO₂ nanoparticles impacted the central nervous system in mice. We measured the levels of dopamine (DA) and its metabolites in several regions of the brain in mice using high performance liquid chromatography (HPLC). HPLC analysis showed that DA and its metabolites were increased in the prefrontal cortex and the neostriatum following prenatal exposure to TiO₂ nanoparticles. The present study highlights the possibility that maternal exposure to TiO₂ nanoparticles might influence the development of the central dopaminergic system in offspring.

Journal

• The Journal of Toxicological Sciences

  The Journal of Toxicological Sciences 35 (5), 749-756, 2010

  The Japanese Society of Toxicology

Keywords

• Brain
• Dopamine system
• Nanoparticle
• Prenatal exposure
• Titanium dioxide (TiO₂)

Details

• CRID: 1390001204900383232
• NII Article ID: 10026669347
• NII Book ID: AN00002808
• DOI: 10.2131/jts.35.749
• COI: 1:CAS:528:DC%2BC3cXhsVCrurrO
• ISSN: 18803989
• ISSN: 03881350
• NDL BIB ID: 10864371
• PubMed: 20930469
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10864371
• Web Site: http://www.jstage.jst.go.jp/article/jts/35/5/35_5_749/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2011149104
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• Abstract License Flag: Disallowed