Development of Laser Plasma X-ray Microbeam Irradiation System and Radiation Biological Application

• Sato Katsutoshi

  Laboratory of Radiation Oncology, Department of Medical Physics and Engineering, Osaka University Graduate School of Medicine

• Nishikino Masaharu

  X-ray Laser Application Group, Quantum Beam Science Directorate, Japan Atomic Energy Agency

• Numasaki Hodaka

  Laboratory of Radiation Oncology, Department of Medical Physics and Engineering, Osaka University Graduate School of Medicine

• Kawachi Tetsuya

  X-ray Laser Application Group, Quantum Beam Science Directorate, Japan Atomic Energy Agency

• Teshima Teruki

  Laboratory of Radiation Oncology, Department of Medical Physics and Engineering, Osaka University Graduate School of Medicine

• Nishimura Hiroaki

  Institute of Laser Engineering, Osaka University

Bibliographic Information

Other Title

• レーザプラズマＸ線マイクロビーム照射装置の開発と放射線生物学研究応用
• レーザプラズマ Xセン マイクロビーム ショウシャ ソウチ ノ カイハツ ト ホウシャセン セイブツガク ケンキュウ オウヨウ

Abstract

Laser plasma x-ray source has the features such as ultra short pulse, high brilliance, monochromaticity, and focusing ability. These features are excellent compared with conventional x-ray source. In order to apply the laser plasma x-ray source to the biomedical study and to more closely research the radiobilogical responce of the cancer cell such as radiation induced bystander effect, we have developed x-ray microbeam system using laser plasma x-ray source. The absorbed dose of laser plasma x-ray was estimated with Gafchromic EBT film and DNA double strand breaks on the cells were detected by immunofluorescence staining. When the cells were irradiated with laser plasma x-ray, the circular regions existing γ-H2AX positive cells were clearly identified. The usefulness of the laser plasma x-ray on the radiobiological study was proved in this research.

Journal

• IEEJ Transactions on Electronics, Information and Systems

  IEEJ Transactions on Electronics, Information and Systems 130 (10), 1800-1805, 2010

  The Institute of Electrical Engineers of Japan

Keywords

• laser plasma x-ray source
• x-ray microbeam
• DNA double strand break
• radiation biology

Details

• CRID: 1390282679585158912
• NII Article ID: 10026694179
• NII Book ID: AN10065950
• DOI: 10.1541/ieejeiss.130.1800
• ISSN: 13488155
• ISSN: 03854221
• NDL BIB ID: 10832007
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10832007
• Web Site: http://www.jstage.jst.go.jp/article/ieejeiss/130/10/130_10_1800/_pdf
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed