Successful treatment of acquired factor V inhibitor with corticosteroids

• YAMANOUCHI Jun

  Department of Bioregulatory Medicine, Ehime University Graduate School of Medicine

• HATO Takaaki

  Department of Bioregulatory Medicine, Ehime University Graduate School of Medicine

Bibliographic Information

Other Title

• プレドニゾロンが著効した後天性凝固第Ｖ因子インヒビターの症例

Abstract

An 82-year old man was admitted for abnormal bleeding following traumatic injury. He has been suffering from psoriasis since 40 years ago. Laboratory findings included PT at <5%, APTT at >200 sec, factor V activity (FV : C) of <3%, and factor V inhibitor of 7 BU/ml. The diagnosis of acquired factor V inhibitor was made. When he received fresh-frozen plasma, his clinical bleeding disappeared. FV : C was then increased very slowly, and his factor V inhibitor was slightly reduced without any treatment. After 11 months at the onset, he had melena and cerebral infarction. Laboratory findings showed the decrease in FV : C (7.8%) and the increase in factor V inhibitor (2.1BU/ml). The patient was treated with prednisolone. Within 14 days after the treatment, the FV : C was increased to the normal level and factor V inhibitor was disappeared, suggesting a very good response to corticosteroid.

Journal

• Japanese Journal of Thrombosis and Hemostasis

  Japanese Journal of Thrombosis and Hemostasis 21 (4), 391-394, 2010

  The Japanese Society on Thrombosis and Hemostasis

Keywords

• factor V inhibitor

Details

• CRID: 1390001204451376128
• NII Article ID: 10026711733
• NII Book ID: AN10353762
• DOI: 10.2491/jjsth.21.391
• ISSN: 18808808
• ISSN: 09157441
• Web Site: https://search.jamas.or.jp/link/ui/2010304488
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed