In Situ Monitoring of Photodynamic Inactivation of the Membrane Functions of Bacteria Using Electrochemical Sensors
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- KATO Hisato
- Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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- KOMAGOE Keiko
- Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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- INOUE Tsuyoshi
- Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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- KATSU Takashi
- Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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The photodynamic inactivation of the membrane functions of bacteria was analyzed in situ, using K+ and tetraphenylphosphonium (TPP+) electrodes, as well as an oxygen electrode. Tetrakis(4-N-trimethylaminophenyl)porphine (TTMAPP) and rose bengal were used, since both dyes act strongly on bacteria, such as Staphylococcus aureus. After a short time lag, they inhibited the respiration of bacteria and increased the permeability of the cytoplasmic membrane to K+, while dissipating the membrane potential. This combination of sensors is quite useful for visualizing the actions of photosensitizers on the bacterial membrane. TTMAPP and rose bengal impaired the bacterial function by reducing the membrane potential within minutes of photo-irradiation.
収録刊行物
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- Analytical Sciences
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Analytical Sciences 26 (10), 1019-1021, 2010
社団法人 日本分析化学会
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詳細情報 詳細情報について
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- CRID
- 1390001204259252992
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- NII論文ID
- 10026785490
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- NII書誌ID
- AA10500785
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- ISSN
- 13482246
- 09106340
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- NDL書誌ID
- 10837989
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- Web Site
- http://id.ndl.go.jp/bib/10837989
- https://ndlsearch.ndl.go.jp/books/R000000004-I10837989
- https://link.springer.com/content/pdf/10.2116/analsci.26.1019.pdf
- https://link.springer.com/article/10.2116/analsci.26.1019/fulltext.html
- http://www.jstage.jst.go.jp/article/analsci/26/10/26_10_1019/_pdf
- https://search.jamas.or.jp/link/ui/2011164319
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- 本文言語コード
- en
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- JaLC
- NDL
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