Isolation, Structure Elucidation, and Asymmetric Synthesis of Biologically Active New Lycopodium Alkaloids

• Takayama Hiromitsu

  Graduate School of Pharmaceutical Sciences, Chiba University

Bibliographic Information

Other Title

• 生物活性リコポジウムアルカロイドの探索と不斉合成
• 生物活性リコポジウムアルカロイドの探索と不斉合性
• セイブツ カッセイ リコポジウムアルカロイド ノ タンサク ト フセイ ゴウセイ

Abstract

Lycopodium alkaloids have been attracting many natural product chemists and synthetic organic chemists due to their important biological activities and unique skeletal characteristics. Our recent chemical investigation on Lycopodium plants, aiming to find novel seed– and lead–molecules for drug development, resulted in the isolation of a number of biologically active alkaloids. Among them, two Fawcettimine–type alkaloids, lycoposerramines–B and –C, four Phlegmarine–type alkaloids, lycoposerramines–V, –W, –X, and –Z, and five Quinolizidine–type alkaloids involving cernuine and cermizine–D, have been synthesized to determine the structures including their absolute configuration.

Journal

• Journal of Synthetic Organic Chemistry, Japan

  Journal of Synthetic Organic Chemistry, Japan 68 (5), 457-469, 2010

  The Society of Synthetic Organic Chemistry, Japan

Keywords

• <I>Lycopodium</I>
• natural product
• alkaloid
• isolation
• asymmetric synthesis
• lycoposerramine
• cernuine
• quinolizidine

Details

• CRID: 1390282680289048320
• NII Article ID: 10026868803
• NII Book ID: AN0024521X
• DOI: 10.5059/yukigoseikyokaishi.68.457
• COI: 1:CAS:528:DC%2BC3cXmslWru78%3D
• ISSN: 18836526
• ISSN: 00379980
• NDL BIB ID: 10701911
• Web Site: http://id.ndl.go.jp/bib/10701911
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10701911
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed