ペプチドチオエステル合成法の最近の進展  [in Japanese] Recent Progress in the Synthetic Methodologies of Peptide Thioesters  [in Japanese]

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Author(s)

    • 重永 章 SHIGENAGA Akira
    • 徳島大学大学院ヘルスバイオサイエンス研究部(薬学系) Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences, The University of Tokushima
    • 佐藤 浩平 SATO Kohei
    • 徳島大学大学院ヘルスバイオサイエンス研究部(薬学系) Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences, The University of Tokushima
    • 大高 章 OTAKA Akira
    • 徳島大学大学院ヘルスバイオサイエンス研究部(薬学系) Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences, The University of Tokushima

Abstract

Investigations of biological processes by using peptide, protein, or its derivative are undoubtedly valuable. In this field, chemical synthesis of native or modified peptides/proteins is indispensable. Fragment condensation strategy, such as thioester method or native chemical ligation, is widely used for chemical synthesis of large peptides and proteins. <i>C</i>-Terminal peptide/protein thioesters have been used as building blocks for the fragment condensation strategy. Therefore, development of methodologies for preparing <i>C</i>-terminal peptide/protein thioesters is one of the most attracting theme in recent peptide/protein chemistry field. In this review, the methodologies for preparing <i>C</i>-terminal peptide/protein thioesters utilizing chemistry, biochemistry, or gene engineering are summarized.

Journal

  • Journal of Synthetic Organic Chemistry, Japan

    Journal of Synthetic Organic Chemistry, Japan 68(9), 911-919, 2010-09-01

    The Society of Synthetic Organic Chemistry, Japan

References:  77

Cited by:  1

Codes

  • NII Article ID (NAID)
    10026870593
  • NII NACSIS-CAT ID (NCID)
    AN0024521X
  • Text Lang
    JPN
  • Article Type
    Journal Article
  • ISSN
    00379980
  • NDL Article ID
    10821083
  • NDL Source Classification
    ZP11(科学技術--化学・化学工業--有機化学・有機化学工業)
  • NDL Call No.
    Z17-256
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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