Characterization of Oxidized and Fragmented Superoxide Dismutase Recruited on Liposome Surface

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Abstract

The interaction of oxidized and fragmented SOD with liposomes has been reported to induce the original SOD-likeenzymatic activity (L.Q. Tuan et al., Langmuir, 24 (2008) 350-354).The effect of several kinds of liposomes on theirrecruited activity of oxidized and fragmented SOD was first investigated. The addition of zwitterionic liposomes withhigh membrane fluidity or that with positive charge was found to increase the SOD-like activity of fragmented SODalthough the negatively charged liposome has no effect on its activity. The SOD-like activity was found to be relatedto the adsorbed amount of the peptides on the liposome surface. The analyzed characteristics of the peptide, togeth-er with the above findings, imply that the liposome-recruited activity of the fragmented SOD was related with therecognition of the SOD fragment by the liposome caused by the combination of electrostatic and hydrophobic inter-action, and hydrogen bonding between the peptide and liposome membrane.

Journal

  • MEMBRANE

    MEMBRANE 33(4), 173-179, 2008-07-01

    THE MEMBRANE SOCIETY OF JAPAN

References:  32

Cited by:  1

Codes

  • NII Article ID (NAID)
    10026876329
  • NII NACSIS-CAT ID (NCID)
    AN0023215X
  • Text Lang
    ENG
  • Article Type
    Journal Article
  • ISSN
    03851036
  • NDL Article ID
    9595296
  • NDL Source Classification
    ZR2(科学技術--生物学--生化学)
  • NDL Call No.
    Z18-1127
  • Data Source
    CJP  CJPref  NDL  J-STAGE 
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