<i>Helicobacter pylori </i>感染と自己免疫疾患， 特に免疫血小板減少性紫斑病

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タイトル別名
  • <i>Helicobacter pylori </i>Infection and Autoimmune Disease Such as Immune Thrombocytopenic Purpura
  • Helicobacter pylori感染と自己免疫疾患,特に免疫血小板減少性紫斑病
  • Helicobacter pylori カンセン ト ジコ メンエキ シッカン トクニ メンエキ ケッショウバン ゲンショウセイ シハンビョウ

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Helicobacter pylori infection is implicated in the pathogenesis of extradigestive diseases such as acne rosacea and idiopathic chronic urticaria and autoimmune diseases such as autoimmune gastric atrophy, rheumatoid arthritis, anti phospholipid antibody syndrome, autoimmune thyroiditis, Sjoegren syndrome, Henoch Schoenlein purpura, and Type B insulin resistance syndrome. H. pylori eradication ameliorated the condition in some, but not all, of those with these autoimmune diseases. Recent studies primarily in Italy and Japan found that H. pylori eradication in those infected with chronic immune thrombocytopenic purpura (ITP) results in a persistent platelet count increase in over half of those treated, suggesting that although pathogenetic mechanisms underlying the relationship between H. pylori infection and autoimmune disease remain unclear, yet-unknown immunological events induced by H. pylori infection almost certainly occur in the development of autoimmune response. A majority of isolated H. pylori strains express human Lewis (Lex and/or Ley determinants and in some strains, Lea,Leb, sialyl-Lex), and H determinants in the O-chain of the surface lipopolysaccharide. Previous studies showed that this molecular mimicry helps the bacterium evade host responses while evoking autoantibody responses to Le antigens. The anti-Ley autoantibody is also reported to promote H. pylori adhesion to gastric epithelial cells, leading to development of gastric atrophy. Moreover, one can hypothesize that anti-Le autoreactive antibodies induced by H. pylori infection are involved in the development of autoimmune diseases, although no clinical studies showing that anti-Le immune responses are involved in the etiology of these autoimmune diseases have been conducted. Proving this hypothesis would require quantitative and qualitative analysis of autoantibodies and T cell functions to Le antigens. High frequent phase variation of Le structures in the O-polysaccharide of H. pylori may influence the immune response of patients to Le antigens.

収録刊行物

  • 感染症学雑誌

    感染症学雑誌 84 (1), 1-8, 2010

    一般社団法人 日本感染症学会

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