'Basal-Plus Therapy' Effectiveness with Insulin Glulisine in Glycemic Control and QOL

• Niiya Tetsuji

  Department of Internal Medicine, Matsuyama Shimin Hospital

• Hashimoto Akiko

  Department of Internal Medicine, Matsuyama Shimin Hospital

• Horimi Shinako

  Department of Internal Medicine, Matsuyama Shimin Hospital

• Nishiyama Mari

  Department of Internal Medicine, Matsuyama Shimin Hospital

• Sekikawa Takashi

  Department of Internal Medicine, Matsuyama Shimin Hospital

• Furukawa Shinya

  Department of Internal Medicine, Matsuyama Shimin Hospital

Bibliographic Information

Other Title

• 経口血糖降下薬＋持効型インスリン製剤併用療法にても効果不十分な２型糖尿病患者におけるインスリングルリジン１日１回追加療法の有用性について―血糖コントロールおよびＱＯＬに及ぼす影響―
• ケイコウ ケットウ コウカヤク ジコウガタ インスリン セイザイ ヘイヨウ リョウホウ ニ テモ コウカ フジュウブン ナ 2ガタ トウニョウビョウ カンジャ ニ オケル インスリングルリジン 1ニチ 1カイ ツイカ リョウホウ ノ ユウヨウセイ ニ ツイテ ケットウ コントロール オヨビ QOL ニ オヨボス エイキョウ

Abstract

We studied Basal-plus therapy effectiveness with the new rapid-acting insulin analog insulin glulisine. Subjects were 17 persons with type 2 diabetes and poor HbA1c levels undergoing basal-supported oral therapy (BOT) . Subjects were administered added insulin glulisine at the evening meal. After 12 weeks of treatment, the insulin glulisine dosage was 4.8 ±1.4 unit. HbA1c decreased significantly at 7.4 ±0.8% to 7.0 ±0.7%, P<0.001, while BMI (23.1 ±3.7 to 23.2 ±3.4 kg/m², P=0.839) and hypoglycemia frequency (1.2 ±3.0 to 0.9 ±1.4 times/month, P=0.729) did not change significantly. We evaluated quality of life (QOL) with the insulin-therapy-related QOL measure questionnaire (ITR-QOL) . After 12 weeks, the number of insulin injections increased, but ITR-QOL did not worsen significantly (99.2 ±12.1 to 97.1 ±15.4, P=0.331) . These results suggest that basal-plus therapy with insulin glulisine aids in glycemic control and QOL in those with type 2 diabetes.<br>

Journal

• Journal of the Japan Diabetes Society

  Journal of the Japan Diabetes Society 53 (9), 675-679, 2010

  THE JAPAN DIABETES SOCIETY

Keywords

• インスリン療法
• 超速効型インスリン
• Quality of Life

Details

• CRID: 1390001204903692160
• NII Article ID: 10026912491
• NII Book ID: AN00166576
• DOI: 10.11213/tonyobyo.53.675
• ISSN: 1881588X
• ISSN: 0021437X
• NDL BIB ID: 10863500
• Web Site: http://id.ndl.go.jp/bib/10863500
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10863500
• Web Site: https://search.jamas.or.jp/link/ui/2011031586
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed