Isocaloric High-protein Diet Ameliorates Systolic Blood Pressure Increase and Cardiac Remodeling Caused by Maternal Caloric Restriction in Adult Mouse Offspring

DOI Web Site 被引用文献6件 参考文献52件
  • KAWAMURA Makoto
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine
  • ITOH Hiroaki
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine Department of Molecular Medicine and Metabolism, Medical Research Institute and Center of Excellence Program for Frontier Research on Molecular Destruction and Reconstitution of Tooth and Bone
  • YURA Shigeo
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency (JST)
  • MOGAMI Haruta
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine
  • FUJII Tsuyoshi
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine
  • MAKINO Hisashi
    Department of Atherosclerosis and Diabetes, National Cardiovascular Center
  • MIYAMOTO Yoshihiro
    Department of Atherosclerosis and Diabetes, National Cardiovascular Center
  • Yoshimasa Yasunao
    Department of Atherosclerosis and Diabetes, National Cardiovascular Center
  • AOE Seiichiro
    Department of Home Economics, Otsuma Women’s University
  • OGAWA Yoshihiro
    Department of Molecular Medicine and Metabolism, Medical Research Institute and Center of Excellence Program for Frontier Research on Molecular Destruction and Reconstitution of Tooth and Bone
  • SAGAWA Norimasa
    Department of Obstetrics and Gynecology, Mie University Graduate School of Medicine
  • KANAYAMA Norio
    Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine
  • KONISHI Ikuo
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine

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抄録

Epidemiologic studies have shown that in utero malnutrition is a risk factor for adult cardiovascular disease (CVD). Recently, we reported a mouse animal model of 30% maternal caloric reduction, in which offspring showed a significant increase in systolic blood pressure (SBP) as well as in cardiac remodeling-associated morphological parameters such as cardiac enlargement and coronary perivascular fibrosis in adulthood. Using a similar animal model, we here demonstrated that an increased level of protein consumption during an undernourished pregnancy (high-protein diet; HPD) corrected for the development of CVD risk factors found in fetal undernourishment with less protein consumption (standardprotein diet; SPD). In contrast, maternal ad libitum feeding with HPD resulted in significantly elevated SBP and cardiac enlargement in offspring at 16 wks. Appropriate maternal protein ingestion might partly protect against the development of CVD risk factors in offspring.

収録刊行物

  • Endocrine Journal

    Endocrine Journal 56 (5), 679-689, 2009

    一般社団法人 日本内分泌学会

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