Effectiveness of scaffolds with pre-seeded mesenchymal stem cells in bone regeneration —Assessment of osteogenic ability of scaffolds implanted under the periosteum of the cranial bone of rats—

DOI HANDLE Web Site PubMed 被引用文献10件 参考文献30件 オープンアクセス
  • BABA Shunsuke
    Department of Regenerative Medicine, Foundation for Biomedical Research and Innovation
  • INOUE Takeomi
    Department of Regenerative Medicine, Foundation for Biomedical Research and Innovation
  • HASHIMOTO Yoshiya
    Department of Biomaterials, Osaka Dental University
  • KIMURA Daisuke
    PhD Course, Graduate School of Dentistry (Periodontology), Osaka Dental University, Department of Periodontology, Osaka Dental University
  • UEDA Masatoshi
    Department of Periodontology, Osaka Dental University
  • SAKAI Kana
    PhD Course, Graduate School of Dentistry (Orthodontics), Osaka Dental University, Department of Orthodontics, Osaka Dental University
  • MATSUMOTO Naoyuki
    Department of Orthodontics, Osaka Dental University
  • HIWA Chiaki
    Core Research Team, Organization of Advanced Science and Technology, Kobe University
  • ADACHI Taiji
    Department of Mechanical Engineering and Science, Kyoto University
  • HOJO Masaki
    Department of Mechanical Engineering and Science, Kyoto University

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  • Effectiveness of scaffolds with pre-seeded mesenchymal stem cells in bone regeneration-Assessment of osteogenic ability of scaffolds implanted under the periosteum of the cranial bone of rats-

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To date, there has been no study on the development of novel regimens based on the following tissue engineering principles: seeding and culturing mesenchymal stem cells (MSCs) on a scaffold before surgery or injecting cultured MSCs into a scaffold during surgery. The purpose of this study was to assess the in vivo osteogenic ability of scaffold/MSCs implanted beneath the periosteum of the cranial bone of rats in three different sample groups: one in which MSCs were pre-seeded and cultured on a scaffold to produce the 3-D woven fabric scaffold/MSC composite using osteo-lineage induction medium, one in which cultured MSCs produced by osteo-lineage induction in cell cultivation flasks were injected into a scaffold during surgery and a control group, in which only the 3-D woven fabric scaffold was implanted. The results indicate that pre-seeding MSCs on a scaffold leads to a higher osteogenic ability than injecting cultured MSCs into a scaffold during surgery.

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