DNA microarray analysis of the liver of mice treated with cobalt chloride

• Matsumoto Kanako

  Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• Fujishiro Hitomi

  Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University

• Satoh Masahiko

  Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University

• Himeno Seiichiro

  Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University

Bibliographic Information

Other Title

• Toxicogenomics/proteomics report: DNA microarray analysis of the liver of mice treated with cobalt chloride

Abstract

To investigate the in vivo effects of cobalt chloride on gene expression at early time points, DNA microarray analysis was performed on the liver of mice injected subcutaneously with cobalt chloride. The liver tissue samples were taken 0.5, 1, and 3 hr after injection. Of the 14 genes up-regulated at 0.5 hr after injection, 7 are related to immunological responses, and 4 of the 7 were found to be involved in the activation of interferon.

Journal

• The Journal of Toxicological Sciences

  The Journal of Toxicological Sciences 35 (6), 935-939, 2010

  The Japanese Society of Toxicology

Keywords

• Cobalt
• DNA microarray
• Liver
• Mouse

Details

• CRID: 1390282679877468544
• NII Article ID: 10026963300
• NII Book ID: AN00002808
• DOI: 10.2131/jts.35.935
• ISSN: 18803989
• ISSN: 03881350
• NDL BIB ID: 10931834
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10931834
• Web Site: http://www.jstage.jst.go.jp/article/jts/35/6/35_6_935/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2011238723
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed