Replacing White Rice with Pre-Germinated Brown Rice Mildly Ameliorates Hyperglycemia and Imbalance of Adipocytokine Levels in Type 2 Diabetes Model Rats

• TORIMITSU Mariko

  Department of Chemistry and Life Science, Nihon University College of Bioresouce Sciences

• NAGASE Ryouhei

  Department of Chemistry and Life Science, Nihon University College of Bioresouce Sciences

• YANAGI Megumi

  Department of Chemistry and Life Science, Nihon University College of Bioresouce Sciences

• HOMMA Miyuki

  Department of Chemistry and Life Science, Nihon University College of Bioresouce Sciences

• SASAI Yousuke

  Department of Chemistry and Life Science, Nihon University College of Bioresouce Sciences

• ITO Yukihiko

  FANCL Research Institute, FANCL Corporation

• HAYAMIZU Kousuke

  FANCL Research Institute, FANCL Corporation

• NONAKA Shouta

  FANCL Research Institute, FANCL Corporation

• HOSONO Takashi

  Department of Chemistry and Life Science, Nihon University College of Bioresouce Sciences

• KISE Mitsuo

  FANCL Research Institute, FANCL Corporation

• SEKI Taiichiro

  Department of Chemistry and Life Science, Nihon University College of Bioresouce Sciences

• ARIGA Toyohiko

  Department of Chemistry and Life Science, Nihon University College of Bioresouce Sciences

抄録

Pre-germinated brown rice (PR) has been developed industrially in order to enhance the nutritional functions of its source material, brown rice (BR). The present study was aimed at clarifying the effect of PR on the type 2 diabetes mellitus. We employed Otsuka Long-Evans Tokushima Fatty (OLETF) rats as a model of type-2 diabetes mellitus. OLETF rats were fed on either PR or white rice (WR) from the age of 4 to 35 wk. Age-matched male Long-Evans Tokushima Otsuka (LETO) rats as a non-diabetic control were also fed on WR. The HbA_1c level in OLETF rats was significantly higher than that in LETO rats. However, the level was lower in PR-fed OLETF rats than in WR-fed OLETF rats. The plasma concentrations of TNF-α and PAI-1 in OLETF rats were higher than those in LETO rats. However, both elevated levels were decreased by the PR-feeding, but not by the WR-feeding. On the other hand, the plasma adiponectin concentration in OLETF rats was lower than that in LETO rats. The decrease in adiponectin level of OLETF rats was ameliorated by PR-feeding. The size of adipocytes in PR-fed OLETF rats was smaller than that in WR-fed OLETF rats. In summary, intake of PR instead of WR ameliorates both insulin resistance and imbalance of the levels of plasma adipocytokines leading to diabetic complications.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ 56 (5), 287-292, 2010

  一般財団法人 学会誌刊行センター

キーワード

• pre-germinated brown rice
• diabetes
• adipocytokine
• adiponectin
• PAI-1

詳細情報

• CRID: 1390282681303118592
• NII論文ID: 10026966020
• NII書誌ID: AA00703822
• DOI: 10.3177/jnsv.56.287
• COI: 1:CAS:528:DC%2BC3cXhsVGqu7bI
• ISSN: 18817742
• ISSN: 03014800
• NDL書誌ID: 10865667
• PubMed: 21228498
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I10865667
• Web Site: https://search.jamas.or.jp/link/ui/2011192137
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可