Prospective Comparative Study of Intravenous Cibenzoline and Disopyramide Therapy in the Treatment of Paroxysmal Atrial Fibrillation After Cardiovascular Surgery

• Komatsu Takashi

  Division of Cardiology, Department of Internal Medicine, Iwate Medical University

• Tachibana Hideaki

  Division of Cardiology, Department of Internal Medicine, Iwate Medical University

• Satoh Yoshihiro

  Division of Cardiology, Department of Internal Medicine, Iwate Medical University

• Ozawa Mahito

  Division of Cardiology, Department of Internal Medicine, Iwate Medical University

• Kunugita Fusanori

  Division of Cardiology, Department of Internal Medicine, Iwate Medical University

• Tashiro Atsushi

  Division of Cardiology, Department of Internal Medicine, Iwate Medical University

• Okabayashi Hitoshi

  Department of Cardiovascular Surgery, Iwate Medical University

• Nakamura Motoyuki

  Division of Cardiology, Department of Internal Medicine, Iwate Medical University

抄録

Background: It has been reported that approximately one-third of patients undergoing cardiovascular surgery experience paroxysmal atrial fibrillation (AF) during the postoperative period. There is, however, little information on the selection of anti-arrhythmic drugs for terminating postoperative paroxysmal AF. Methods and Results: Between April 2007 and March 2009, 118 patients (76 men, 42 women, mean age 68±10 years) who had postoperative paroxysmal AF lasting ≥30 min were randomly assigned to receive either iv cibenzoline (70 mg, n=60) or disopyramide (50 mg, n=58) for terminating postoperative paroxysmal AF. The success rate of iv cibenzoline therapy (47%) was significantly greater than that of iv disopyramide therapy (24%; P<0.05). To identify clinical factors to increase the termination efficacy of iv cibenzoline, multivariate logistic regression was used to adjust for several covariates and to generate adjusted odds ratios (OR). The significant variables for the termination of paroxysmal AF after iv cibenzoline therapy were pretreatment with oral β-adrenergic blockers (OR =8.224, P=0.030) and smaller left atrial dimensions (OR =0.879, P=0.039). Conclusions: The efficacy of iv cibenzoline for the termination of postoperative paroxysmal AF was significantly better than that of disopyramide, especially in patients with pre-administration of oral β-adrenergic blockers and those with smaller left atrium.  (Circ J 2010; 74: 1859 - 1865)<br>

収録刊行物

• Circulation Journal

  Circulation Journal 74 (9), 1859-1865, 2010

  一般社団法人 日本循環器学会

キーワード

• Cardiac surgery
• Cibenzoline
• Circadian rhythm
• Disopyramide
• Paroxysmal atrial fibrillation

詳細情報

• CRID: 1390282680081548672
• NII論文ID: 10026971305
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-10-0023
• ISSN: 13474820
• ISSN: 13469843
• Web Site: https://www.jstage.jst.go.jp/article/circj/74/9/74_CJ-10-0023/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2011065092
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可