レーザーアンケージング刺激による海馬ＣＡ１錐体細胞の樹状突起上のＥＰＳＰの時間・空間加重特性の解析

• 米山 誠

  玉川大学脳科学研究所

• 福島 康弘

  玉川大学脳科学研究所

• 小島 比呂志

  玉川大学工学部

• 塚田 稔

  玉川大学脳科学研究所

書誌事項

タイトル別名

• Analysis of the Spatial-Temporal Characteristics of Synaptic EPSP Summation on the Dendritic Trees of Hippocampal CA1 Pyramidal Neurons as Revealed by Laser Uncaging Stimulation

抄録

Synaptic strength is modified by the temporal coincidence of synaptic inputs without Back-Propagating Action Potentials (BPAP) in CA1 pyramidal neurons. To clarify the interactive mechanisms related to associative LTP without BPAP, local stimulation (paired stimuli) was applied onto the dendrites by using high-speed laser uncaging stimulating equipment. Spatially, when the spatial distance between paired stimuli was less than 10 micrometer, nonlinear amplification in EPSP summation was observed. Temporally, in the time window (-20 to +20ms), supralinear amplification was observed. These results are closely related to the spatiotemporal-characteristic for the associative LTP without BPAP.

収録刊行物

• 日本神経回路学会誌

  日本神経回路学会誌 17 (1), 2-11, 2010

  日本神経回路学会

詳細情報

• CRID: 1390282679443107328
• NII論文ID: 10027011141
• NII書誌ID: AA11658570
• DOI: 10.3902/jnns.17.2
• ISSN: 18830455
• ISSN: 1340766X
• Web Site: https://search.jamas.or.jp/link/ui/2012120831
• 本文言語コード: ja
• データソース種別:
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  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可