Effect of a hot water-soluble extraction from <i>Grifola frondosa</i> on the viability of a human monocyte cell line exposed to mitomycin C

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  • Kodama Noriko
    Department of Basic Educational Center for Pharmacy, Kobe Pharmaceutical University
  • Mizuno Shigeto
    Department of Medical Pharmaceutics, Kobe Pharmaceutical University
  • Asakawa Akihiro
    Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
  • Inui Akio
    Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences
  • Nanba Hiroaki
    Kobe Pharmaceutical University

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  • Effect of a hot water-soluble extraction from Grifola frondosa on the viability of a human monocyte cell line exposed to mitomycin C

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Abstract

<p>The effects of a hot water-soluble extract of Grifola frondosa on the viability of multiple immune cell lines were examined in vitro. The extract and the 1000-cut extract, a low molecular weight fraction, improved the viability of a human monocyte cell line, THP-1, treated by the anticancer drug mitomycin C. DNA microarray and immunoassay results revealed increases in interleukin (IL)-8 expression by THP-1 cells in response to the 1000-cut extract. These data suggest that the extract would enhance the immune system through induction of IL-8 production by human blood monocytes, which leads to activated neutrophils.</p>

Journal

  • Mycoscience

    Mycoscience 51 (2), 134-138, 2010

    The Mycological Society of Japan

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