1歳児の下顎骨に生じた小円形細胞腫瘍の1例  [in Japanese] A case of small round cell tumor arising in the mandible of a 1-year-old girl  [in Japanese]

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Author(s)

    • 蔵原 慎一 KURAHARA Shin-ichi
    • 九州大学大学院歯学研究院口腔顎顔面病態学講座口腔顎顔面外科学分野 Section of Oral and Maxillofacial Surgery, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University
    • 中村 誠司 NAKAMURA Seiji
    • 九州大学大学院歯学研究院口腔顎顔面病態学講座顎顔面腫瘍制御学分野 Section of Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University
    • 鬼丸 満穂 [他] ONIMARU Mitsuho
    • 九州大学大学院医学研究院病態制御学講座病理病態学分野 Pathophsiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University
    • 石橋 浩晃 ISHIBASHI Hiroaki
    • 島根大学医学部歯科口腔外科学講座 Department of Oral and Maxillofacial Surgery, School of Medicine, Shimane University
    • 佐々木 匡理 SASAKI Masanori
    • 九州大学大学院歯学研究院口腔顎顔面病態学講座口腔顎顔面外科学分野 Section of Oral and Maxillofacial Surgery, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University
    • 白砂 兼光 SHIRASUNA Kanemitsu
    • 九州大学大学院歯学研究院口腔顎顔面病態学講座口腔顎顔面外科学分野 Section of Oral and Maxillofacial Surgery, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University

Abstract

Neuroblastoma, Ewing sarcoma, rhabdomyosarcoma, and malignant lymphoma consist of undifferentiated small round cells with scanty cytoplasm and are classified as so-called small round cell tumors. These tumors are often difficult to distinguish on light microscopy and to make a definitive diagnosis because they have poor histological characteristics.<br>We report a case of a small round cell tumor arising in the mandible of a 1-year 9-month-old girl. She was referred to our department because of swelling in the left side of the mandible in November 2003. Computed tomographic(CT)scans revealed a soft tissue density area expanding buccolingually in the mandible. An incisional biopsy was done under general anesthesia for a suspected diagnosis of an intra-osseous carcinoma of the mandible. A neurogenic malignant tumor was suspected from the biopsy specimen because of CD56 activity.<br>Based on clinical, radiological, and histopathologic findings, a radical resection of the tumor was performed via a submandibular approach in March 2004. Following hemimandibulectomy, primary reconstruction of the defect was performed, using a titanium plate.<br>Because the tumor cells were positive immunohistochemisty for neural markers in the surgical specimen, the definitive diagnosis was a malignant small round cell tumor with nueroendocrine features. Five years after surgery, there has been no evidence of recurrence or metastasis.

Neuroblastoma, Ewing sarcoma, rhabdomyosarcoma, and malignant lymphoma consist of undifferentiated small round cells with scanty cytoplasm and are classified as so-called small round cell tumors. These tumors are often difficult to distinguish on light microscopy and to make a definitive diagnosis because they have poor histological characteristics.<br>We report a case of a small round cell tumor arising in the mandible of a 1-year 9-month-old girl. She was referred to our department because of swelling in the left side of the mandible in November 2003. Computed tomographic(CT)scans revealed a soft tissue density area expanding buccolingually in the mandible. An incisional biopsy was done under general anesthesia for a suspected diagnosis of an intra-osseous carcinoma of the mandible. A neurogenic malignant tumor was suspected from the biopsy specimen because of CD56 activity.<br>Based on clinical, radiological, and histopathologic findings, a radical resection of the tumor was performed via a submandibular approach in March 2004. Following hemimandibulectomy, primary reconstruction of the defect was performed, using a titanium plate.<br>Because the tumor cells were positive immunohistochemisty for neural markers in the surgical specimen, the definitive diagnosis was a malignant small round cell tumor with nueroendocrine features. Five years after surgery, there has been no evidence of recurrence or metastasis.

Journal

  • Japanese Journal of Oral and Maxillofacial Surgery

    Japanese Journal of Oral and Maxillofacial Surgery 55(6), 305-309, 2009-06-20

    Japanese Society of Oral and Maxillofacial Surgeons

References:  17

Codes

  • NII Article ID (NAID)
    10027090653
  • NII NACSIS-CAT ID (NCID)
    AN00189163
  • Text Lang
    JPN
  • Article Type
    NOT
  • ISSN
    00215163
  • NDL Article ID
    10355815
  • NDL Source Classification
    ZS44(科学技術--医学--歯科学・口腔外科学)
  • NDL Call No.
    Z19-145
  • Data Source
    CJP  NDL  J-STAGE 
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