CCL7 and CCL25 promote RANKL-induced osteoclast formation

DOI 58 References

Bibliographic Information

Other Title
  • ＣＣＬ７およびＣＣＬ２５はＲＡＮＫＬによって誘導される破骨細胞形成を促進する

Search this article

Abstract

Bone resorption by osteoclasts involves migration of the osteoclast precursor cells in the initial stages, followed by differentiation of these cells into mature osteoclasts. Chemokines play essential roles in the chemotaxis of hematopoietic cells. In this study, we established the effects of CCL7(CC chemokine ligand 7) and CCL25(CC chemokine ligand 25) on the receptor activation of NF-kB ligand (RANKL)-stimulated osteoclast differentiation. CCL7 and CCL25 were produced from IL-1- and VitaminD3-stimulated ST2 cells, an osteoblastic cell line, simultaneously with RANKL. On the other hand, CCR2(CC chemokine receptor 2) and CCR9(CC chemokine receptor 9) are well known as a CCL7 receptor and CCL25 receptor, respectively, expressed in RAW264.7 cells, osteoclast precursor cells. Recombinant CCL7 and CCL25 increased the number of RANKL-induced multinucleate cells. Further, neutralization of CCL7 and CCL25 by antibody reduced RANKL-stimulated osteoclast differentiation by approximately 50% Identical results were obtained from RANKL-stimulated bone marrow cells. Taken together, these results suggest that CCL7 and CCL25 may play an important role in RANKL-induced osteoclast formation.<BR>Nihon Shishubyo Gakkai Kaishi (J Jpn Soc Periodontol) 51(1) : 51-61, 2009.

Journal

References(58)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top