Bisphenol-A contents in materials used in pediatric dentistry

DOI 19 References
  • Kaneko Shoko
    Department of Pediatric Dentistry, Showa University, School of Dentistry
  • Manabe Atsufumi
    Department of Operative Dentistry, Showa University, School of Dentistry
  • Numazawa Satoshi
    Department of Biochemical Toxicology, Showa University, School of Pharmaceutical Sciences
  • Itoh Kazuo
    Department of Operative Dentistry, Showa University, School of Dentistry
  • Inoue Mitsuko
    Department of Pediatric Dentistry, Showa University, School of Dentistry
  • Yoshida Takemi
    Department of Biochemical Toxicology, Showa University, School of Pharmaceutical Sciences
  • Hisamitsu Hisashi
    Department of Operative Dentistry, Showa University, School of Dentistry
  • Sasa Ryuji
    Department of Pediatric Dentistry, Showa University, School of Dentistry

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Abstract

Bisphenol-A (BPA) has been shown to be an endocrine disruptor in animals. We have previously demonstrated selective extraction of BPA from dental materials and its detection by gas chromatography-mass spectrometry. In the present study, this same procedure was employed for the detection of BPA in materials routinely used in pediatric dentistry—commercial resin composites, fissure sealants, compomers, and dentin bonding agents. In unpolymerized materials, significant BPA contamination was detected in 2 of 3 resin composites, 2 of 5 fissure sealants, and all bonding agents and intermediate resins tested. Moreover, in most cases, incubation of polymerized materials for 24 h resulted in release of BPA into phosphate-buffered saline. However, the highest level of BPA released (89.5 ng/g polymerized material) was still far less than the reported lowest dose that produces endocrine disruption in experimental animals (2μg/kg/d).

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