Effect of Leptin on Regulation of Renal 25-hydroxyvitamin D3 Metabolism and Maintenance of Calcium Homeostasis

• Matsunuma Ayako

  Section of Oral Biochemistry, Department of Oral Function and Molecular Biology, Ohu University School of Dentistry

• Horiuchi Noboru

  Section of Oral Biochemistry, Department of Oral Function and Molecular Biology, Ohu University School of Dentistry

抄録

Leptin, a hormone secreted by adipocytes, acts on the hypothalamus to reduce appetite and inhibit body weight gain. Leptin has pleiotropic actions on bone, gonadal hormone secretion, the pancreas, immune tissues, and vascular organs. Leptin-deficient (ob/ob) mice, used in many studies defining leptin actions, have low bone mineral density (BMD) and retarded femoral growth. Loss of leptin function contributes to aberrant regulation of renal 25-hydroxyvitamin D₃ metabolism by increasing the gene expression of renal 1α-hydroxylase, which catalyzes 1,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃] synthesis and thus elevates serum 1,25(OH)₂D₃ concentrations. Excess 1,25(OH)₂D₃ results in increased calcium absorption in the intestine and stimulates bone resorption, resulting in reduced BMD, especially in long bones. Finally, leptin deficiency increases serum calcium concentrations; excess calcium in blood is excreted in urine.

収録刊行物

• Journal of Oral Biosciences

  Journal of Oral Biosciences 49 (2), 97-104, 2007

  歯科基礎医学会

キーワード

• leptin
• vitamin D
• 1α-hydroxylase
• bone mineral density

詳細情報

• CRID: 1390001205213954688
• NII論文ID: 130004475642
• NII論文ID: 10027102463
• NII書誌ID: AA11896386
• DOI: 10.2330/joralbiosci.49.97
• ISSN: 18803865
• ISSN: 13490079
• Web Site: https://search.jamas.or.jp/link/ui/2007288025
• 本文言語コード: en
• データソース種別:
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• 抄録ライセンスフラグ: 使用不可